Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis
Heijligers, Malou; Peeters, Andrea; van Montfoort, Aafke; Nijsten, Joyce; Janssen, Etienne; Gunnewiek, Femke Klein; de Rooy, Rick; van Golde, Ron; Coonen, Edith; Meijer-Hoogeveen, Madelon; Broekmans, Frank; van der Hoeven, Mark; Arens, Yvonne; de Die-Smulders, Christine
(2019) Fertility and Sterility, volume 111, issue 6, pp. 1151 - 1158
(Article)
Abstract
Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD). Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural
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conception (NC). Setting: University hospital. Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC. Intervention(s): PGD. Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones. Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems. Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. Trial registration number: NCT02149485.
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Keywords: Preimplantation genetic diagnosis, child, preimplantation genetic testing follow-up
ISSN: 0015-0282
Publisher: Elsevier Inc.
Note: Funding Information: This study was funded by ZonMw ( 70-71 300-98-106 ) and the Guy Peeters Fund (Academic Fund, MUMC+). Funding Information: Author Broekmans reports personal fees from Advisory board for Ferring, Advisory board for Merck Serono, Advisory board for Gedeon Richter, and Educational activities from Ferring, outside the submitted work. Author Heijligers reports grants from ZonMw and Guy Peeters funding, during the conduct of the study. Authors de Die and Arens report grants from ZonMw, during the conduct of the study. All other authors report nothing to disclose. Funding Information: Supported by ZonMw (70-71 300-98-106) and the Guy Peeters Fund (Academic Fund, MUMC+). M.H. reports grants from ZonMw and Guy Peeters. A.P. has nothing to disclose. A.v.M. has nothing to disclose. J.N. has nothing to disclose. E.J. has nothing to disclose. F.K.G. has nothing to disclose. R.d.R. has nothing to disclose. R.v.G. has nothing to disclose. E.C. has nothing to disclose. M.M.-H. has nothing to disclose. F.B. reports fees from Ferring, Merck Serono, and Gedeon Richter. M.v.d.H. has nothing to disclose. Y.A. reports grants from ZonMw. C.d.D.-S. reports grants from ZonMw. Supported by ZonMw ( 70-71 300-98-106) and the Guy Peeters Fund (Academic Fund, MUMC+). The authors thank the children and their parents for their contribution to this study. M.H. reports grants from ZonMw and Guy Peeters. A.P. has nothing to disclose. A.v.M. has nothing to disclose. J.N. has nothing to disclose. E.J. has nothing to disclose. F.K.G. has nothing to disclose. R.d.R. has nothing to disclose. R.v.G. has nothing to disclose. E.C. has nothing to disclose. M.M.-H. has nothing to disclose. F.B. reports fees from Ferring, Merck Serono, and Gedeon Richter. M.v.d.H. has nothing to disclose. Y.A. reports grants from ZonMw. C.d.D.-S. reports grants from ZonMw. Supported by ZonMw ( 70-71 300-98-106) and the Guy Peeters Fund (Academic Fund, MUMC+). Publisher Copyright: © 2019 American Society for Reproductive Medicine
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