Prevalence and vascular risk factors of basal ganglia calcifications in patients at risk for cerebrovascular disease
Dutch acute stroke study investigators., (DUST)
(2020) Journal of neuroradiology, volume 47, issue 5, pp. 337 - 342
(Article)
Abstract
Background and purpose: Risk factors for and meaning of basal ganglia calcifications outside Fahr syndrome are poorly understood. We aimed to assess the prevalence of basal ganglia calcifications and the association with vascular risk factors. Materials and methods: 1133 patients suspected of acute ischemic stroke from the Dutch acute stroke
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(DUST)study who underwent thin-slice unenhanced brain CT were analyzed. Basal ganglia calcifications were scored bilaterally as absent, mild (dot), moderate (multiple dots or single artery)and severe (confluent). Uni- and multivariable logistic regression analysis was used to determine possible risk factors (age, gender, history of stroke, smoking, hypertension, diabetes mellitus, hyperlipidemia, body mass index (BMI), renal function and family history of cardiovascular disease under 60 years)for presence of basal ganglia calcifications and ordinal regression analysis for severity of basal ganglia calcifications. Results: Mean age was 67.4 years (SD: 13.8), 56.8% were male. 337 (29.7%)patients had basal ganglia calcifications, of which 196 (58%)were mild, 103 (31%)moderate, 38 (11%)severe. In multivariable logistic regression analysis, age (OR: 1.02, 95% CI 1.01–1.03, P < 0.01)and BMI (OR: 0.95, 95% CI 0.91–0.98, p 0.01)were significantly associated with the presence of basal ganglia calcifications. Ordinal regression analysis gave comparable results. Age (OR: 1.02, 95% CI 1.01–1.03, P < 0.01)and BMI (OR: 0.95, 95% CI 0.92–0.99, P 0.01)were significantly associated with severity of basal ganglia calcifications. Conclusions: In this study with patients suspected of acute ischemic stroke, basal ganglia calcifications were common and significantly associated with older age and lower BMI.
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Keywords: Basal ganglia, Multidetector-row computed tomography, Risk factors, Clinical Neurology, Radiological and Ultrasound Technology, Radiology Nuclear Medicine and imaging, Journal Article
ISSN: 0150-9861
Publisher: Elsevier Masson
Note: Funding Information: The DUST study was supported by grants from the Dutch Heart Foundation (grant numbers 2008 T034) and the NutsOhra Foundation (grant number 0903–012). J.W.D. and R.A.P.T. were supported by a grant from TTW/NOW (projectnumber 14732). Funding Information: The Dutch acute stroke study (DUST) investigators are: Majoie CB, Roos YB (Academic Medical Center, Amsterdam); Duijm LE, Keizer K (Catharina Hospital, Eindhoven); van der Lugt A, Dippel DW (Erasmus Medical Center, Rotterdam); Droogh-de Greve KE, Bienfait HP (Gelre Hospitals, Apeldoorn); van Walderveen MA, Wermer MJH (Leiden University Medical Center, Leiden); Lycklama ? Nijeholt GJ, Boiten J (Medical Center Haaglanden, The Hague); Duyndam DA, Kwa VI (Onze Lieve Vrouwe Gasthuis, Amsterdam); Meijer FJ, van Dijk EJ (Radboud University Nijmegen Medical Center, Nijmegen); Kesselring FO, Hofmeijer J (Rijnstate Hospital, Arnhem); Vos JA, Schonewille WJ (St. Antonius Hospital, Nieuwegein); van Rooij WJ, de Kort PL (St. Elisabeth Hospital, Tilburg); Pleiter CC, Bakker SL (St. Franciscus Hospital, Rotterdam); Bot JC, Visser MC (VU Medical Center, Amsterdam); Velthuis BK, van der Schaaf IC, Dankbaar JW, Mali WP, van Seeters T, Horsch AD, Niesten JM, Biessels GJ, Kappelle LJ, Luitse MJ, van der Graaf Y (University Medical Center Utrecht, Utrecht). All centers are located in the Netherlands. Funding Information: The DUST study was supported by grants from the Heart Foundation (grant numbers 2008 T034) and the NutsOhra Foundation (grant number 0903–012) and were supported by a grant from TTW/NOW (projectnumber 14732). Publisher Copyright: © 2019 Elsevier Masson SAS
(Peer reviewed)