Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders
Díaz-Caneja, Covadonga M.; Schnack, Hugo; Martínez, Kenia; Santonja, Javier; Alemán-Gomez, Yasser; Pina-Camacho, Laura; Moreno, Carmen; Fraguas, David; Arango, Celso; Parellada, Mara; Janssen, Joost
(2019) Human Brain Mapping, volume 40, issue 5, pp. 1643 - 1653
(Article)
Abstract
Autism spectrum disorders (ASD) and early-onset psychosis (EOP) are neurodevelopmental disorders that share genetic, clinical and cognitive facets; it is unclear if these disorders also share spatially overlapping cortical thickness (CT) and surface area (SA) abnormalities. MRI scans of 30 ASD, 29 patients with early-onset first-episode psychosis (EO-FEP) and 26
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typically developing controls (TD) (age range 10–18 years) were analyzed by the FreeSurfer suite to calculate vertex-wise estimates of CT, SA, and cortical volume. Two publicly available datasets of ASD and EOP (age range 7–18 years and 5–17 years, respectively) were used for replication analysis. ASD and EO-FEP had spatially overlapping areas of cortical thinning and reduced SA in the bilateral insula (all p’s <.00002); 37% of all left insular vertices presenting with significant cortical thinning and 20% (left insula) and 61% (right insula) of insular vertices displaying decreased SA overlapped across both disorders. In both disorders, SA deficits contributed more to cortical volume decreases than reductions in CT did. This finding, as well as the novel finding of an absence of spatial overlap (for ASD) or marginal overlap (for EOP) of deficits in CT and SA, was replicated in the two nonoverlapping independent samples. The insula appears to be a region with transdiagnostic vulnerability for deficits in CT and SA. The finding of nonexistent or small spatial overlap between CT and SA deficits in young people with ASD and psychosis may point to the involvement of common aberrant early neurodevelopmental mechanisms in their pathophysiology.
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Keywords: autism spectrum disorder, cortical surface area, cortical thickness, first-episode psychosis, MRI, neurodevelopment, Anatomy, Radiological and Ultrasound Technology, Radiology Nuclear Medicine and imaging, Neurology, Clinical Neurology
ISSN: 1065-9471
Publisher: Wiley-Liss Inc.
Note: Funding Information: ERA-NET NEURON, Grant/Award Number: PIM2010ERN-00642; Fundación Alicia Koplowitz; Fundación Familia Alonso; Madrid Regional Government, Grant/Award Number: S2017/BMD-3740; Redes temáticas, Grant/ Award Number: ISCIII-G03/032; European Commission, Grant/Award Numbers: FP7-HEALTH-2013-2.2.1-2-602478, FP7-HEALTH-2013-2.2.1-2-603196, FP7-HEALTH-2009-2.2.1-3-242114, FP7-HEALTH-2009-2.2.1-2-241909; EU H2020, IMI-2 Joint Undertaking, Grant Agreements: 115916 (project PRISM), and 777394 (project AIMS-2-TRIALS); CDTI under the CENIT Program, Grant/Award Number: AMIT Project; RETICS, Grant/Award Number: RD06/0011 (REM-TAP Network); Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III, Grant/Award Numbers: PI17/01249, PI17/01997, PI17/ 00819, PIE16/00055, PI14/00815, PI13/02112, PI12/01303, PI11/02877, PI10/02989, PS09/ 01442, PI05/0678, PI02/1248; cofinanced by ERDF funds from the European Commission, “A way of making Europe”; CIBERSAM. Support for Funding Information: information ERA-NET NEURON, Grant/Award Number: PIM2010ERN-00642; Fundaci?n Alicia Koplowitz; Fundaci?n Familia Alonso; Madrid Regional Government, Grant/Award Number: S2017/BMD-3740; Redes tem?ticas, Grant/Award Number: ISCIII-G03/032; European Commission, Grant/Award Numbers: FP7- HEALTH-2013-2.2.1-2-602478, FP7-HEALTH-2013-2.2.1-2-603196, FP7-HEALTH-2009-2.2.1-3-242114, FP7-HEALTH-2009-2.2.1-2-241909; EU H2020, IMI-2 Joint Undertaking, Grant Agreements: 115916 (project PRISM), and 777394 (project AIMS-2-TRIALS); CDTI under the CENIT Program, Grant/Award Number: AMIT Project; RETICS, Grant/Award Number: RD06/0011 (REM-TAP Network); Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III, Grant/Award Numbers: PI17/01249, PI17/01997, PI17/00819, PIE16/00055, PI14/00815, PI13/02112, PI12/01303, PI11/02877, PI10/02989, PS09/01442, PI05/0678, PI02/1248; cofinanced by ERDF funds from the European Commission, ?A way of making Europe?; CIBERSAM; Support for ABIDE-NYU Langone coordination and data aggregation was partially provided by National Institute of Mental Health, Grant/Award Numbers: K23MH087770, R03MH09632, BRAINSRO1MH094639-01; National Institutes of Health, Grant/Award Number: R21MH084126; Autism Speaks, and the Leon Levy Foundation; and gifts from Joseph P. Healey and the Stavros Niarchos FoundationWe thank all individuals and their families for their participation. This work was supported by CIBERSAM; Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities (PI02/1248, PI05/0678, PS09/01442, PI10/02989, PI11/02877, PI12/01303, PI13/02112, PI14/00815, PI17/01997, PI17/00819, PI17/01249, PIE16/00055), co-financed by the ERDF from the European Commission ?A way of making Europe?, EU 7FP (FP7-HEALTH-2009-2.2.1-2-241909, FP7-HEALTH-2009-2.2.1-3-242114, FP7-HEALTH-2013-2.2.1-2-603196, and FP7-HEALTH-2013-2.2.1-2-602478); EU H2020 (IMI-2 Joint Undertaking under grant agreements 115916 (project PRISM) and 777394 (project AIMS-2-TRIALS)), RETICS-RD06/0011 (REM-TAP Network); Redes tem?ticas ISCIII-G03/032; CDTI under the CENIT Program (AMIT Project); Madrid Regional Government (S2017/BMD-3740); Fundaci?n Familia Alonso, Fundaci?n Alicia Koplowitz; and ERA-NET NEURON (PIM2010ERN-00642). We thank the members of the ABIDE and Dr. Milham, of the NYU Medical Center and INDI team (http://fcon_1000.projects.nitrc.org) for supporting the ABIDE effort. Support for ABIDE-NYU Langone coordination and data aggregation was partially provided by NIMH (K23MH087770, R03MH09632, BRAINSRO1MH094639-01), NIH (R21MH084126), Autism Speaks, and the Leon Levy Foundation, gifts from Joseph P Healey and the Stavros Niarchos Foundation. Funding Information: ABIDE-NYU Langone coordination and data aggregation was partially provided by National Institute of Mental Health, Grant/Award Numbers: K23MH087770, R03MH09632, BRAINSRO1MH094639-01; National Institutes of Health, Grant/Award Number: R21MH084126; Autism Speaks, and the Leon Levy Foundation; and gifts from Joseph P. Healey and the Stavros Niarchos Foundation Funding Information: We thank all individuals and their families for their participation. This work was supported by CIBERSAM; Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities (PI02/1248, PI05/0678, PS09/01442, PI10/02989, PI11/02877, PI12/01303, PI13/02112, PI14/00815, PI17/01997, PI17/00819, PI17/01249, PIE16/00055), co-financed by the ERDF from the European Commission “A way of making Europe”, EU 7FP (FP7-HEALTH-2009-2.2.1-2-241909, FP7-HEALTH-2009-2.2.1-3-242114, FP7-HEALTH-2013-2.2.1-2-603196, and FP7-HEALTH-2013-2.2.1-2-602478); EU H2020 (IMI-2 Joint Undertaking under grant agreements 115916 (project PRISM) and 777394 (project AIMS-2-TRIALS)), RETICS-RD06/0011 (REM-TAP Network); Redes temáticas ISCIII-G03/032; CDTI under the CENIT Program (AMIT Project); Madrid Regional Government (S2017/BMD-3740); Fundación Familia Alonso, Fundación Alicia Koplowitz; and ERA-NET NEURON (PIM2010ERN-00642). We thank the members of the ABIDE and Dr. Milham, of the NYU Medical Center and INDI team (http://fcon_1000.projects.nitrc.org) for supporting the ABIDE effort. Support for ABIDE-NYU Langone coordination and data aggregation was partially provided by NIMH (K23MH087770, R03MH09632, BRAINSRO1MH094639-01), NIH (R21MH084126), Autism Speaks, and the Leon Levy Foundation, gifts from Joseph P Healey and the Stavros Niarchos Foundation. Publisher Copyright: © 2018 Wiley Periodicals, Inc.
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