Morbidity and mortality associated with respiratory virus infections in allogeneic hematopoietic cell transplant: Too little defense or harmful immunity?
Versluys, Anne Birgitta; Boelens, Jaap Jan
(2018) Frontiers in Microbiology, volume 9, issue NOV, pp. 1 - 7
(Article)
Abstract
The impact on morbidity and mortality of Community Acquired Respiratory Virus (CARV) infections in patients undergoing Allogeneic Hematopoietic Cell Transplant (HCT) is widely studied. Here we give an overview of the current literature on the incidence and chance of progression to severe disease in this highly immune compromised population. We
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discuss the issue whether it is predominantly direct viral damage that causes clinical deterioration, or that it is in fact the allogeneic immuneresponse to the virus that is most important. This is an important question as it will guide therapeutic decision making. It asks for further collaborative studies focusing on sensitive surveillance with PCR techniques and relating clinical data with parameters of immune reconstitution.
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Keywords: Allogeneic transplant of hematopoietic stem cells, Alloimmunity and transplantation, Lung disease, Outcome, Respiratory virus infection, Microbiology, Microbiology (medical)
ISSN: 1664-302X
Publisher: Frontiers Media S. A.
Note: Funding Information: Fisher, C. E., Preiksaitis, C. M., Lease, E. D., Edelman, J., Kirby, K. A., Leisenring, W. M., et al. (2016). Symptomatic respiratory virus infection and chronic lung allograft dysfunction. Clin. Infect. Dis. 62, 313–319. doi: 10.1093/cid/ civ871 Fonseca, W., Lukacs, N. W., and Ptaschinski, C. (2018). Factors affecting the immunity to respiratory syncytial virus: from epigenetics to microbiome. Front. Immunol. 9:226. doi: 10.3389/fimmu.2018.00226 Green, M. L. (2017). Viral pneumonia in patients with hematopoietic cell transplantation and hematologic malignancies. Clin. Chest Med. 38, 295–305. doi: 10.1016/j.ccm.2016.12.009 Hirsch, H. H., Martino, R., Ward, K. N., Boeckh, M., Einsele, H., and Ljungman, P. (2013). Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus. Clin. Infect. Dis. 56, 258–266. doi: 10.1093/cid/cis844 Hutspardol, S., Essa, M., Richardson, S., Schechter, T., Ali, M., Krueger, J., et al. (2015). Significant transplantation-related mortality from respiratory virus infections within the first one hundred days in children after hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 21, 1802–1807. doi: 10.1016/j.bbmt.2015.06.015 Jagasia, M. H., Greinix, H. T., Arora, M., Williams, K. M., Wolff, D., Cowen, E. W., et al. (2015). National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report. Biol. Blood Marrow Transplant. 21, 389e1–401e1. doi: 10.1016/j.bbmt.2014.12.001 Kim, Y. J., Guthrie, K. A., Waghmare, A., Walsh, E. E., Falsey, A. R., Kuypers, J., et al. (2014). Respiratory syncytial virus in hematopoietic cell transplant recipients: factors determining progression to lower respiratory tract disease. J. Infect. Dis. 209, 1195–1204. doi: 10.1093/infdis/jit832 Kmeid, J., Vanichanan, J., Shah, D. P., El Chaer, F., Azzi, J., Ariza-Heredia, E. J., et al. (2016). Outcomes of influenza infections in hematopoietic cell transplant recipients: application of an immunodeficiency scoring index. Biol. Blood Marrow Transplant. 22, 542–548. doi: 10.1016/j.bbmt.2015.11.015 Kumar, D., Erdman, D., Keshavjee, S., Peret, T., Tellier, R., Hadjiliadis, D., et al. (2005). Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. Am. J. Transplant. 5, 2031–2036. doi: 10.1111/j.1600-6143.2005.00971.x Kumar, D., Husain, S., Chen, M. H., Moussa, G., Himsworth, D., Manuel, O., et al. (2010). A prospective molecular surveillance study evaluating the clinical impact of community-acquired respiratory viruses in lung transplant recipients. Transplantation 89, 1028–1033. doi: 10.1097/TP.0b013e3181 d05a71 Man, W. H., de Steenhuijsen Piters, W. A., and Bogaert, D. (2017). The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat. Rev. Microbiol. 15, 259–270. doi: 10.1038/nrmicro.2017.14 Moe, N., Pedersen, B., Nordbo, S. A., Skanke, L. H., Krokstad, S., Smyrnaios, A., et al. (2016). Respiratory virus detection and clinical diagnosis in children attending day care. PLoS ONE 11:e0159196. doi: 10.1371/journal.pone. 0159196 Molinos-Quintana, A., Pérez-de Soto C., Gómez-Rosa, M., Pérez-Simón, J. A., and Pérez-Hurtado, J. M. (2013). Intravenous ribavirin for respiratory syncytial viral infections in pediatric hematopoietic SCT recipients. Bone Marrow Transplant. 48, 265–268. doi: 10.1038/bmt.2012.134 Panoskaltsis-Mortari, A., Griese, M., Madtes, D. K., Belperio, J. A., Haddad, I. Y., Folz, R. J., et al. (2011). An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am. J. Respir. Crit. Care Med. 183, 1262–1279. doi: 10.1164/rccm.2007-413ST Pinana, J. L., Madrid, S., Perez, A., Hernandez-Boluda, J. C., Gimenez, E., Terol, M. J., et al. (2018). Epidemiologic and clinical characteristics of coronavirus and bocavirus respiratory infections after allogeneic stem cell transplantation: a prospective single-center study. Biol. Blood Marrow Transplant. 24, 563–570. doi: 10.1016/j.bbmt.2017.11.001 Renaud, C., Xie, H., Seo, S., Kuypers, J., Cent, A., Corey, L., et al. (2013). Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients. Biol. Blood Marrow Transplant. 19, 1220–1226. doi: 10.1016/j.bbmt.2013. 05.005 Robinson, J. L., Grenier, D., MacLusky, I., and Allen, U. D. (2015). Respiratory syncytial virus infections in pediatric transplant recipients: A Canadian paediatric surveillance program study. Pediatr. Transplant. 19, 659–662. doi: 10.1111/petr.12553 Seo, S., Renaud, C., Kuypers, J. M., Chiu, C. Y., Huang, M. L., Samayoa, E., et al. (2015). Idiopathic pneumonia syndrome after hematopoietic cell transplantation: evidence of occult infectious etiologies. Blood 125, 3789–3797. doi: 10.1182/blood-2014-12-617035 Seo, S., Waghmare, A., Scott, E. M., Xie, H., Kuypers, J. M., Hackman, R. C., et al. (2017). Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality. Haematologica 102, 1120–1130. doi: 10.3324/haematol.2016. 153767 Shah, D. P., Ghantoji, S. S., Ariza-Heredia, E. J., Shah, J. N., El Taoum, K. K., Shah, P. K., et al. (2014). Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections. Blood 123, 3263–3268. doi: 10.1182/blood-2013-12-541359 Shah, D. P., Ghantoji, S. S., Mulanovich, V. E., Ariza-Heredia, E. J., and Chemaly, R. F. (2012). Management of respiratory viral infections in hematopoietic cell transplant recipients. Am. J. Blood Res. 2, 203–218. Publisher Copyright: © 2007 - 2018 Frontiers Media S.A.
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