The use of mushroom-forming fungi for the production of N-glycosylated therapeutic proteins

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The use of mushroom-forming fungi for the production of N-glycosylated therapeutic proteins
 
Berends, E.; Scholtmeijer, Karin; Wösten, H.A.B.; Bosch, H.J.; Lugones, L.G.
(2009) Trends in Microbiology, volume 17, issue 10, pp. 439 - 443
(Article)
Abstract
The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. This requires cost-effective production platforms that display correct and homogeneous N-glycosylation. Based on recent results, we propose to use mushroom-forming basidiomycetes for the production of N-glycosylated therapeutic proteins.
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DOI: https://doi.org/10.1016/j.tim.2009.07.002
ISSN: 0966-842X
Publisher: Elsevier
 
 
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