Advanced glycation end products, measured in skin, vs. HbA1c in children with type 1 diabetes mellitus

Abstract

Background and objective: Advanced glycation end products (AGEs) are considered major contributors to microvascular and macrovascular complications in adult patients with diabetes mellitus. AGEs can be measured non-invasively with skin autofluorescence (sAF). The primary aim was to determine sAF values in children with type 1 diabetes mellitus and to study correlations between sAF values and HbA1c and mean HbA1c over the year prior to measurement Research design and methods: In children with type 1 diabetes mellitus, sAF values were measured using the AGE Reader®. Laboratory and anthropometric values were extracted from medical charts. Correlations were studied using Pearson's correlation coefficient. Multivariable linear regression analysis was conducted to evaluate the effect of multiple study parameters on sAF values. Results: The mean sAF value was 1.33±0.36arbitrary units (AU) in children with type 1 diabetes mellitus (n=144). sAF values correlated positively with HbA1c measured at the same time (r=0.485; p