Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis
van der Pal, Sylvia; van Buuren, Stef; Anderson, Peter J.; Bartmann, Peter; Baumann, Nicole; Cheong, Jeanie L.Y.; Darlow, Brian A.; Doyle, Lex W.; Evensen, Kari Anne I.; Horwood, John; Indredavik, Marit S.; Johnson, Samantha; Marlow, Neil; Mendonça, Marina; Ni, Yanyan; Wolke, Dieter; Woodward, Lianne; Verrips, Erik; Petrou, Stavros; Bolbocean, Corneliu
(2023) PharmacoEconomics, volume 41, issue 1, pp. 93 - 105
(Article)
Abstract
Background and Objective: Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between
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VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood. Methods: Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models. Results: VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain. Conclusions: VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.
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Keywords: Adolescent, Adult, Birth Weight, Child, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Very Low Birth Weight/psychology, Prospective Studies, Quality of Life, Young Adult, Public Health, Environmental and Occupational Health, Health Policy, Pharmacology
ISSN: 1170-7690
Publisher: Adis International Ltd
Note: Funding Information: This work was supported by grant 733280 from the European Commission as part of the Research on European Children and Adults Born Preterm (RECAP) Consortium Preterm Project, a European Union Horizon 2020 study to construct a platform combining data from cohort studies of very preterm birth in Europe. The Victorian Infant Collaborative Study was supported by grants 491246 and 546519 from the National Health and Medical Research Council of Australia. The New Zealand Very Low Birthweight Follow up Study was supported by project grant 12-129 from the Health Research Council of New Zealand and additional funding from the Cure Kids Charitable Foundation. Participation by the Norwegian University of Science and Technology in RECAP was supported by the Research Council of Norway, project no. 283791. SP receives support as a UK National Institute for Health Research Senior Investigator (NF-SI-0616-10103) and from the UK National Institute for Health Research Applied Research Collaboration Oxford and Thames Valley. Publisher Copyright: © 2022, The Author(s).
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