Proteomic analysis of serum in workers exposed to diesel engine exhaust
Rahman, M.L.; Bassig, Bryan A.; Dai, Yufei; Wong, Jason Y Y; Blechter, Batel; Hosgood, H. Dean; Ren, Danzhi; Duan, Huawei; Niu, Yong; Xu, Jun; Fu, Wei; Meliefste, Kees; Zhou, Baosen; Yang, Jufang; Ye, Meng; Jia, Xiaowei; Meng, Tao; Meng, Tao; Bin, Ping; Silverman, D.T.; Vermeulen, Roel; Rothman, Nat; Zheng, Yuxin; Lan, Qing
(2022) Environmental and Molecular Mutagenesis, volume 63, issue 1, pp. 18 - 28
(Article)
Abstract
Diesel engine exhaust (DEE) is classified as a Group 1 human carcinogen. Using a targeted proteomics approach, we aimed to identify proteins associated with DEE and characterize these markers to understand the mechanisms of DEE-induced carcinogenicity. In this cross-sectional molecular epidemiology study, we measured elemental carbon (EC) using a personal
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air monitor and quantified 1317 targeted proteins in the serum using the SOMAScan assay (SOMALogic) among 19 diesel exposed factory workers and 19 unexposed controls. We used linear regressions to identify proteins associated with DEE and examined their exposure-response relationship across levels of EC using linear trend tests. We further examined pathway enrichment of DEE-related proteins using MetaCore. Occupational exposure to DEE was associated with altered levels of 22 serum proteins (permutation p
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Keywords: SOMAscan, carcinogenesis, diesel engine exhaust, Elemental carbon, lung cancer, proteomics, Taverne
ISSN: 0893-6692
Publisher: Wiley-Liss Inc.
(Peer reviewed)
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