Antibacterial and anti-inflammatory properties of host defense peptides against Staphylococcus aureus

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Antibacterial and anti-inflammatory properties of host defense peptides against Staphylococcus aureus
 
Cecotto, Leonardo; van Kessel, Kok; Wolfert, Margreet A; Vogely, Charles; van der Wal, Bart; Weinans, Harrie; van Strijp, Jos; Amin Yavari, Saber
(2022) iScience, volume 25, issue 10, pp. 1 - 17
(Article)
Abstract
Cationic host defense peptides (HDPs) are a promising alternative to antibiotics in the fight against Staphylococcus aureus infections. In this study, we investigated the antibacterial and immunomodulatory properties of three HDPs namely IDR-1018, CATH-2, and LL-37. Although all three HDPs significantly inhibited LPS-induced activation of human macrophages, only CATH-2 prevented ... read more
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Keywords: Immunology, Microbiology, General
DOI: https://doi.org/10.1016/j.isci.2022.105211
ISSN: 2589-0042
Publisher: Elsevier
Note: Funding Information: We thank Lisanne de Vor for assistance with acquiring images by confocal microscopy, and Dr. Michiel Croes for the meaningful discussions and data interpretations during the first stages of the research. The collaboration project is cofounded by the PPP Allowance made available by Health ∼ Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. This research also received co-funding from the EU's H2020 research and innovation program under Marie S. Curie co-fund RESCUE grant agreement No 801540. This publication is part of the project DARTBAC (with project number NWA.1292.19.354 of the research program NWA-ORC which is (partly) financed by the Dutch Research Council (NWO). Conceptualization, S.A.; Methodology L.C. K.K. J.S. H.W. and S.A.; Investigation L.C. and M.W.; Writing – Original draft, L.C. K.K. J.S. and S.A; Writing – Review & Editing, L.C. K.K. M.W, C.V. B.W. H.W. J.S. and S.A; Funding Acquisition, H.W. and S.A.; Resources, K.K. H.W. J.S. and S.A; Supervision, K.K. H.W. J.S. and S.A. The authors declare no competing interests. Funding Information: We thank Lisanne de Vor for assistance with acquiring images by confocal microscopy, and Dr. Michiel Croes for the meaningful discussions and data interpretations during the first stages of the research. The collaboration project is cofounded by the PPP Allowance made available by Health ∼ Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. This research also received co-funding from the EU’s H2020 research and innovation program under Marie S. Curie co-fund RESCUE grant agreement No 801540 . This publication is part of the project DARTBAC (with project number NWA.1292.19.354 of the research program NWA-ORC which is (partly) financed by the Dutch Research Council (NWO). Publisher Copyright: © 2022 The Author(s)
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