Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

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Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
 
ENIGMA Eating Disorders Working Group; Danner, U.N.; van Elburg, A.A.
(2022) Biological Psychiatry, volume 92, issue 9, pp. 730 - 738
(Article)
Abstract
BACKGROUND: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain ... read more
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Keywords: BMI, Cortical thickness, MRI, Subcortical volume, Surface area, Taverne, Biological Psychiatry
DOI: https://doi.org/10.1016/j.biopsych.2022.04.022
ISSN: 0006-3223
Publisher: Elsevier USA
Note: Funding Information: This work was supported by the Carus Promotionskolleg (to KB), Ministerio de Igualdad (Grant No. 234/09 [to SA-P]), Generalitat de Catalunya (Grant No. 2009 SGR 1119 [to SA-P and LLaz] and Grant No. 2017 SGR 4881 [to JC-F]), National Institutes of Health (Grant No. R21MH86017 [to AB-G and CEW], Grant No. R01MH113588 [to AB-G, WHK, and CEW], Grant No. RC1MH088678 [to JLG, KSL, NLZ, and JAK], and Grant No. R01MH042984-17A1 [to WHK]), Biomedical Research Centre (to ICC), Alicia Koplowitz Foundation (Grant No. DN040546 [to JC-F]), German Ministry for Education and Research (Grant Nos. 01GV0602 and 01GV0623 [to BD, BH-D, JSS, and GGvP]), National Institute of Mental Health (Grant Nos. R01MH105662 and R01MH093535 [to JDF], Grant Nos. K23MH080135 and R01MH096777 [to GKWF and MES], Grant No. K23MH112949 [to SSK], and Grant No. K23MH118418 [to LAB]), Centre for Addiction and Mental Health Alternative Funding Plan Innovation Fund (to ASK, AEM, and ANV), Swiss Anorexia Nervosa Foundation (Project No. 19-12 [to L-KK and GFM] and Project No. 57-16 [to JJS] and to SE), Palatin Foundation (to L-KK and GFM), Gottfried and Julia Bangerter-Rhyner-Foundation (to L-KK and GFM), Weston A. Price Foundation (to WHK), Carlos III Research Institute of the Spanish Ministry of Health (Grant No. FIS PI040829 [to LLaz]), National Institute for Health Research Mental Health Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King's College London (ICC, OO, and UHS), German Research Foundation (Grant Nos. SI 2087/2-1 and BR 4852/1-1 [to JJS] and Grant Nos. EH 367/5-1 and EH 367/7-1 [to SE]), Research Council of Norway (Grant Nos. 288083 and 223273 [to CKT]), South-Eastern Norway Regional Health Authority (Grant Nos. 2019069, 2021070, and 500189 [to CKT]), National Institute of Health Research Senior Investigator Award (to UHS), NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (to LAB), and Technische Universität Dresden SFB 940 (to SE). This work was further supported by the European Union Horizon 2020 EarlyCause project (Grant No. 848158 [to EW]). The ENIGMA Working Group acknowledges the National Institutes of Health Big Data to Knowledge award for foundational support and consortium development (Grant No. U54 EB020403 [to PMT]). All data produced in the present study are available upon reasonable request to the authors. The authors report no biomedical financial interests or potential conflicts of interest. Funding Information: This work was supported by the Carus Promotionskolleg (to KB), Ministerio de Igualdad (Grant No. 234/09 [to SA-P]), Generalitat de Catalunya (Grant No. 2009 SGR 1119 [to SA-P and LLaz] and Grant No. 2017 SGR 4881 [to JC-F]), National Institutes of Health (Grant No. R21MH86017 [to AB-G and CEW], Grant No. R01MH113588 [to AB-G, WHK, and CEW], Grant No. RC1MH088678 [to JLG, KSL, NLZ, and JAK], and Grant No. R01MH042984-17A1 [to WHK]), Biomedical Research Centre (to ICC), Alicia Koplowitz Foundation (Grant No. DN040546 [to JC-F]), German Ministry for Education and Research (Grant Nos. 01GV0602 and 01GV0623 [to BD, BH-D, JSS, and GGvP]), National Institute of Mental Health (Grant Nos. R01MH105662 and R01MH093535 [to JDF], Grant Nos. K23MH080135 and R01MH096777 [to GKWF and MES], Grant No. K23MH112949 [to SSK], and Grant No. K23MH118418 [to LAB]), Centre for Addiction and Mental Health Alternative Funding Plan Innovation Fund (to ASK, AEM, and ANV), Swiss Anorexia Nervosa Foundation (Project No. 19-12 [to L-KK and GFM] and Project No. 57-16 [to JJS] and to SE), Palatin Foundation (to L-KK and GFM), Gottfried and Julia Bangerter-Rhyner-Foundation (to L-KK and GFM), Weston A. Price Foundation (to WHK), Carlos III Research Institute of the Spanish Ministry of Health (Grant No. FIS PI040829 [to LLaz]), National Institute for Health Research Mental Health Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King’s College London (ICC, OO, and UHS), German Research Foundation (Grant Nos. SI 2087/2-1 and BR 4852/1-1 [to JJS] and Grant Nos. EH 367/5-1 and EH 367/7-1 [to SE]), Research Council of Norway (Grant Nos. 288083 and 223273 [to CKT]), South-Eastern Norway Regional Health Authority (Grant Nos. 2019069 , 2021070 , and 500189 [to CKT]), National Institute of Health Research Senior Investigator Award (to UHS), NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (to LAB), and Technische Universität Dresden SFB 940 (to SE). This work was further supported by the European Union Horizon 2020 EarlyCause project (Grant No. 848158 [to EW]). Funding Information: The ENIGMA Working Group acknowledges the National Institutes of Health Big Data to Knowledge award for foundational support and consortium development (Grant No. U54 EB020403 [to PMT]). Publisher Copyright: © 2022 Society of Biological Psychiatry
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