Non-Invasive Monitoring of Inflammation in Inflammatory Bowel Disease Patients during Prolonged Exercise via Exhaled Breath Volatile Organic Compounds
Henderson, B.; Meurs, J.; Lamers, C.R.; Batista, G.L.; Materić, D.; Bertinetto, C.G.; Bongers, C.C.W.G.; Holzinger, R.; Harren, F.J.M.; Jansen, J.J.; Hopman, M.T.E.; Cristescu, S.M.
(2022) Metabolites, volume 12, issue 3, pp. 1 - 10
(Article)
Abstract
The aim of this study was to investigate volatile organic compounds (VOCs) in exhaled breath as possible non-invasive markers to monitor the inflammatory response in inflammatory bowel disease (IBD) patients as a result of repeated and prolonged moderate-intensity exercise. We included 18 IBD patients and 19 non-IBD individuals who each
... read more
completed a 30, 40, or 50 km walking exercise over three consecutive days. Breath and blood samples were taken before the start of the exercise event and every day post-exercise to assess changes in the VOC profiles and cytokine concentrations. Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) was used to measure exhaled breath VOCs. Multivariate analysis, particularly ANOVA-simultaneous component analysis (ASCA), was employed to extract relevant ions related to exercise and IBD. Prolonged exercise induces a similar response in breath butanoic acid and plasma cytokines for participants with or without IBD. Butanoic acid showed a significant correlation with the cytokine IL-6, indicating that butanoic acid could be a potential non-invasive marker for exercise-induced inflammation. The findings are relevant in monitoring personalized IBD management.
show less
Download/Full Text
Keywords: Breath analysis, Butanoic acid, Exercise, Inflammatory bowel disease, PTR-ToF-MS, Volatile organic compounds, Endocrinology, Diabetes and Metabolism, Biochemistry, Molecular Biology
ISSN: 2218-1989
Publisher: MDPI Multidisciplinary Digital Publishing Institute
Note: Funding Information: This work was supported by H2020 Marie Skłodowska-Curie Actions Innovative Training Network: Ion-Molecule Processes for Analytical Chemistry Technologies (IMPACT, grant number 674911), H2020-SFS-2018-2020 Fact-based personalized nutrition for the young (NUTRISHIELD, grant number SEP-210497548), The Netherlands Earth System Science Centre (NESSC) research network (grant number 024.002.001), and The Dutch Research Agenda (NWA) for Startimpuls “Meten en Detecteren van Gezond Gedrag” (grant number 400.17.604). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
(Peer reviewed)
See more statistics about this item