Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases ...
Maier, Robert M.; Zhu, Zhihong; Lee, Sang Hong; Trzaskowski, Maciej; Ruderfer, Douglas M.; Stahl, Eli A.; Ripke, Stephan; Wray, Naomi R.; Yang, Jian; Visscher, Peter M.; Robinson, Matthew R.; Forstner, Andreas J.; Mcquillin, Andrew; Trubetskoy, Vassily; Wang, Weiqing; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; De Leeuw, Christiaan A.; Whitehead Pavlides, Jennifer M.; Olde Loohuis, Loes M.; Pers, Tune H.; Lee, Phil H.; Charney, Alexander W.; Dobbyn, Amanda L.; Huckins, Laura; Boocock, James; Giambartolomei, Claudia; Roussos, Panos; Mullins, Niamh; Awasthi, Swapnil; Agerbo, Esben; Als, Thomas D.; Pedersen, Carsten Bøcker; Grove, Jakob; Kupka, Ralph; Regeer, Eline J.; Anjorin, Adebayo; Casas, Miquel; Mahon, Pamela B.; Allardyce, Judith; Escott-Price, Valentina; Forty, Liz; Fraser, Christine; Kogevinas, Manolis; Frank, Josef; Streit, Fabian; Strohmaier, Jana; Treutlein, Jens; Witt, Stephanie H.; Kennedy, James L.; Strauss, John S.; Garnham, Julie; O'donovan, Claire; Slaney, Claire; Steinberg, Stacy; Thorgeirsson, Thorgeir E.; Hautzinger, Martin; Steffens, Michael; Perlis, Roy H.; Sánchez-Mora, Cristina; Hipolito, Maria; Lawson, William B.; Nwulia, Evaristus A.; Levy, Shawn E.; Foroud, Tatiana M.; Jamain, Stéphane; Young, Allan H.; Mckay, James D.; Albani, Diego; Zandi, Peter; Potash, James B.; Zhang, Peng; Raymond Depaulo, J.; Bergen, Sarah E.; Juréus, Anders; Karlsson, Robert; Kandaswamy, Radhika; Mcguffin, Peter; Rivera, Margarita; Lissowska, Jolanta; Cruceanu, Cristiana; Lucae, Susanne; Cervantes, Pablo; Budde, Monika; Gade, Katrin; Heilbronner, Urs; Pedersen, Marianne Giørtz; Morris, Derek W.; Weickert, Cynthia Shannon; Weickert, Thomas W.; Macintyre, Donald J.; Lawrence, Jacob; Elvsåshagen, Torbjørn; Smeland, Olav B.; Djurovic, Srdjan; Xi, Simon; Green, Elaine K.; Czerski, Piotr M.; Hauser, Joanna; Xu, Wei; Vedder, Helmut; Oruc, Lilijana; Spijker, Anne T.; Gordon, Scott D.; Medland, Sarah E.; Curtis, David; Mühleisen, Thomas W.; Badner, Judith; Scheftner, William A.; Sigurdsson, Engilbert; Schork, Nicholas J.; Schatzberg, Alan F.; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hansen, Christine Søholm; Knowles, James A.; Szelinger, Szabolcs; Montgomery, Grant W.; Boks, Marco; Adolfsson, Annelie Nordin; Hoffmann, Per; Bauer, Michael; Pfennig, Andrea; Leber, Markus; Kittel-Schneider, Sarah; Reif, Andreas; Del-Favero, Jurgen; Fischer, Sascha B.; Herms, Stefan; Reinbold, Céline S.; Degenhardt, Franziska; Koller, Anna C.; Maaser, Anna; Ori, Anil; Dale, Anders M.; Fan, Chun Chieh; Greenwood, Tiffany A.; Nievergelt, Caroline M.; Shehktman, Tatyana; Shilling, Paul D.; Byerley, William; Bunney, William; Alliey-Rodriguez, Ney; Clarke, Toni Kim; Liu, Chunyu; Coryell, William; Akil, Huda; Burmeister, Margit; Flickinger, Matthew; Li, Jun Z.; Mcinnis, Melvin G.; Meng, Fan; Thompson, Robert C.; Watson, Stanley J.; Zollner, Sebastian; Guan, Weihua; Green, Melissa J.; Craig, David; Sobell, Janet L.; Milani, Lili; Gordon-Smith, Katherine; Knott, Sarah V.; Perry, Amy; Parra, José Guzman; Mayoral, Fermin; Rivas, Fabio; Rice, John P.; Barchas, Jack D.; Børglum, Anders D.; Mortensen, Preben Bo; Mors, Ole; Grigoroiu-Serbanescu, Maria; Bellivier, Frank; Etain, Bruno; Leboyer, Marion; Ramos-Quiroga, Josep Antoni; Agartz, Ingrid; Amin, Farooq; Azevedo, Maria H.; Bass, Nicholas; Black, Donald W.; Blackwood, Douglas H.R.; Bruggeman, Richard; Buccola, Nancy G.; Choudhury, Khalid; Cloninger, C. Robert; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Datta, Susmita; Donohoe, Gary J.; Duan, Jubao; Dudbridge, Frank; Fanous, Ayman; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Gill, Michael; Gurling, Hugh; De Haan, Lieuwe; Hamshere, Marian L.; Hartmann, Annette M.; Holmans, Peter A.; Kahn, René S.; Keller, Matthew C.; Kenny, Elaine; Kirov, George K.; Krabbendam, Lydia; Krasucki, Robert; Lencz, Todd; Levinson, Douglas F.; Lieberman, Jeffrey A.; Lin, Dan Yu; Linszen, Don H.; Magnusson, Patrik K.E.; Maier, Wolfgang; Malhotra, Anil K.; Mattheisen, Manuel; Mattingsdal, Morten; Mccarroll, Steven A.; Medeiros, Helena; Melle, Ingrid; Milanova, Vihra; Myin-Germeys, Inez; Neale, Benjamin M.; Ophoff, Roel A.; Owen, Michael J.; Pimm, Jonathan; Purcell, Shaun M.; Puri, Vinay; Quested, Digby J.; Rossin, Lizzy; Sanders, Alan R.; Shi, Jianxin; Sklar, Pamela; St Clair, David; Stroup, T. Scott; Van Os, Jim; Wiersma, Durk; Zammit, Stanley(Nature Publishing Group, 2018-12-01)
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to ...
Couch, Fergus J; Kuchenbaecker, Karoline B; Michailidou, Kyriaki; Mendoza-Fandino, Gustavo A; Nord, Silje; Lilyquist, Janna; Olswold, Curtis; Hallberg, Emily; Agata, Simona; Ahsan, Habibul; Aittomäki, Kristiina; Ambrosone, Christine; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Arun, Banu K; Arver, Brita; Barile, Monica; Barkardottir, Rosa B; Barrowdale, Daniel; Beckmann, Lars; Beckmann, Matthias W; Benitez, Javier; Blank, Stephanie V; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Buys, Saundra S; Caldes, Trinidad; Caligo, Maria A; Canzian, Federico; Carpenter, Jane; Chang-Claude, Jenny; Chanock, Stephen J; Chung, Wendy K; Claes, Kathleen B M; Cox, Angela; Cross, Simon S; Cunningham, Julie M; Czene, Kamila; Daly, Mary B; Damiola, Francesca; Darabi, Hatef; de la Hoya, Miguel; Devilee, Peter; Diez, Orland; Ding, Yuan C; Dolcetti, Riccardo; Domchek, Susan M; Dorfling, Cecilia M; Dos-Santos-Silva, Isabel; Dumont, Martine; Dunning, Alison M; Eccles, Diana M; Ehrencrona, Hans; Ekici, Arif B; Eliassen, Heather; Ellis, Steve; Fasching, Peter A; Figueroa, Jonine; Flesch-Janys, Dieter; Försti, Asta; Fostira, Florentia; Foulkes, William D; Friebel, Tara; Friedman, Eitan; Frost, Debra; Gabrielson, Marike; Gammon, Marilie D; Ganz, Patricia A; Gapstur, Susan M; Garber, Judy; Gaudet, Mia M; Gayther, Simon A; Gerdes, Anne-Marie; Ghoussaini, Maya; Giles, Graham G; Glendon, Gord; Godwin, Andrew K; Goldberg, Mark S; Goldgar, David E; González-Neira, Anna; Greene, Mark H; Gronwald, Jacek; Guénel, Pascal; Gunter, Marc; Haeberle, Lothar; Haiman, Christopher A; Hamann, Ute; Hansen, Thomas V O; Hart, Steven; Healey, Sue; Heikkinen, Tuomas; Henderson, Brian E; Herzog, Josef; Hogervorst, Frans B L; Hollestelle, Antoinette; Hooning, Maartje J; Hoover, Robert N; Hopper, John L; Humphreys, Keith; Hunter, David J; Huzarski, Tomasz; Imyanitov, Evgeny N; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Janavicius, Ramunas; Jensen, Uffe Birk; John, Esther M; Jones, Michael; Kabisch, Maria; Kar, Siddhartha; Karlan, Beth Y; Khan, Sofia; Khaw, Kay-Tee; Kibriya, Muhammad G; Knight, Julia A; Ko, Yon-Dschun; Konstantopoulou, Irene; Kosma, Veli-Matti; Kristensen, Vessela; Kwong, Ava; Laitman, Yael; Lambrechts, Diether; Lazaro, Conxi; Lee, Eunjung; Le Marchand, Loic; Lester, Jenny; Lindblom, Annika; Lindor, Noralane; Lindstrom, Sara; Liu, Jianjun; Long, Jirong; Lubinski, Jan; Mai, Phuong L; Makalic, Enes; Malone, Kathleen E; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Frederik; Martens, John W M; McGuffog, Lesley; Meindl, Alfons; Miller, Austin; Milne, Roger L; Miron, Penelope; Montagna, Marco; Mazoyer, Sylvie; Mulligan, Anna M; Muranen, Taru A; Nathanson, Katherine L; Neuhausen, Susan L; Nevanlinna, Heli; Nordestgaard, Børge G; Nussbaum, Robert L; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I; Olson, Janet E; Osorio, Ana; Park, Sue K; Peeters, Petra H; Peissel, Bernard; Peterlongo, Paolo; Peto, Julian; Phelan, Catherine M; Pilarski, Robert; Poppe, Bruce; Pylkäs, Katri; Radice, Paolo; Rahman, Nazneen; Rantala, Johanna; Rappaport, Christine; Rennert, Gad; Richardson, Andrea; Robson, Mark; Romieu, Isabelle; Rudolph, Anja; Rutgers, Emiel J; Sanchez, Maria-Jose; Santella, Regina M; Sawyer, Elinor J; Schmidt, Daniel F; Schmidt, Marjanka K; Schmutzler, Rita K; Schumacher, Fredrick; Scott, Rodney; Senter, Leigha; Sharma, Priyanka; Simard, Jacques; Singer, Christian F; Sinilnikova, Olga M; Soucy, Penny; Southey, Melissa; Steinemann, Doris; Stenmark-Askmalm, Marie; Stoppa-Lyonnet, Dominique; Swerdlow, Anthony; Szabo, Csilla I; Tamimi, Rulla; Tapper, William; Teixeira, Manuel R; Teo, Soo-Hwang; Terry, Mary B; Thomassen, Mads; Thompson, Deborah; Tihomirova, Laima; Toland, Amanda E; Tollenaar, Robert A E M; Tomlinson, Ian; Truong, Thérèse; Tsimiklis, Helen; Teulé, Alex; Tumino, Rosario; Tung, Nadine; Turnbull, Clare; Ursin, Giski; van Deurzen, Carolien H M; van Rensburg, Elizabeth J; Varon-Mateeva, Raymonda; Wang, Zhaoming; Wang-Gohrke, Shan; Weiderpass, Elisabete; Weitzel, Jeffrey N; Whittemore, Alice; Wildiers, Hans; Winqvist, Robert; Yang, Xiaohong R; Yannoukakos, Drakoulis; Yao, Song; Zamora, M Pilar; Zheng, Wei; Hall, Per; Kraft, Peter; Vachon, Celine; Slager, Susan; Chenevix-Trench, Georgia; Pharoah, Paul D P; Monteiro, Alvaro A N; García-Closas, Montserrat; Easton, Douglas F; Antoniou, Antonis C(Nature Publishing Group, 2016-04-27)
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast ...