Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Zamora-Ros, R.; Lujan-Barroso, L.; Achaintre, D.; Franceschi, S.; Kyrø, C.; Overvad, K.; Tjønneland, A.; Truong, T.; Lecuyer, L.; Boutron-Ruault, M.-C.; Katzke, V.; Johnson, T.S.; Schulze, M.B.; Trichopoulou, A.; Peppa, E.; La Vechia, C.; Masala, G.; Pala, V.; Panico, S.; Tumino, R.; Ricceri, F.; Skeie, G.; Ramón Quirós, J.; Rodriguez-Barranco, M.; Amiano, P.; Chirlaque, M.-D.; Ardanaz, E.; Almquist, M.; Hennings, J.; Vermeulen, R.; Wareham, N.J.; Tong, T.Y.N.; Aune, D.; Byrnes, G.; Weiderpass, E.; Scalbert, A.; Rinaldi, S.; Agudo, A.
(2021) American Journal of Clinical Nutrition, volume 113, issue 1, pp. 162 - 171
(Article)
Abstract
Background: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking. Objectives: The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC
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(the European Prospective Investigation into Cancer and Nutrition). Methods: A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 not otherwise specified TC tumors) and 512 strictly matched controls. Blood polyphenol concentrations were analyzed by HPLC coupled to tandem MS after enzymatic hydrolysis. Results: Using multivariable-adjusted conditional logistic regression models, caffeic acid (ORlog2: 0.55; 95% CI: 0.33, 0.93) and its dehydrogenated metabolite, 3,4-dihydroxyphenylpropionic acid (ORlog2: 0.84; 95% CI: 0.71, 0.99), were inversely associated with differentiated TC risk. Similar results were observed for papillary TC, but not for follicular TC. Ferulic acid was also inversely associated only with papillary TC (ORlog2: 0.68; 95% CI: 0.51, 0.91). However, none of these relations was significant after Bonferroni correction for multiple testing. No association was observed for any of the remaining polyphenols with total differentiated, papillary, or follicular TC. Conclusions: Blood polyphenol concentrations were mostly not associated with differentiated TC risk in women, although our study raises the possibility that high blood concentrations of caffeic, 3,4-dihydroxyphenylpropionic, and ferulic acids may be related to a lower papillary TC risk.
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Keywords: Biomarkers, EPIC, Nested case–control study, Polyphenol, Thyroid cancer, Medicine (miscellaneous), Nutrition and Dietetics
ISSN: 0002-9165
Publisher: American Society for Nutrition
Note: Funding Information: Supported by the Instituto de Salud Carlos III (ISCIII) ?Miguel Servet? program grant CP15/00100 (cofunded by the European Regional Development Fund and the European Social Fund) (to RZ-R). The coordination of EPIC (the European Prospective Investigation into Cancer and Nutrition) is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle G?n?rale de l?Education Nationale, and Institut National de la Sant? et de la Recherche M?dicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (Netherlands), and the National Institute for Public Health and the Environment (RIVM, Bilthoven, Netherlands); Health Research Fund (FIS)?ISCIII, the Regional Governments of Andaluc?a, Asturias, Basque Country, Murcia, and Navarra, and the Catalan Institute of Oncology?ICO (Spain); Swedish Cancer Society, Swedish Research Council, and the County Councils of Sk?ne and V?sterbotten (Sweden); Cancer Research UK grant 14136 to EPIC-Norfolk and grants C570/A16491 and C8221/A19170 to EPIC-Oxford, and Medical Research Council grant 1000143 to EPIC-Norfolk and grant MR/M012190/1 to EPIC-Oxford (United Kingdom). Publisher Copyright: © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition. All rights reserved.
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