Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

Lu, Y.; Corradi, C.; Gentiluomo, M.; López de Maturana, E.; Theodoropoulos, G.E.; Roth, S.; Maiello, E.; Morelli, L.; Archibugi, L.; Izbicki, J.R.; Sarlós, P.; Kiudelis, V.; Oliverius, M.; Aoki, M.N.; Vashist, Y.; van Eijck, C.H.J.; Gazouli, M.; Talar-Wojnarowska, R.; Mambrini, A.; Pezzilli, R.; Bueno-de-Mesquita, B.; Hegyi, P.; Souček, P.; Neoptolemos, J.P.; Di Franco, G.; Sperti, C.; Kauffmann, E.F.; Hlaváč, V.; Uzunoğlu, F.G.; Ermini, S.; Małecka-Panas, E.; Lucchesi, M.; Vanella, G.; Dijk, F.; Mohelníková-Duchoňová, B.; Bambi, F.; Petrone, M.C.; Jamroziak, K.; Guo, F.; Kolarova, K.; Capretti, G.; Milanetto, A.C.; Ginocchi, L.; Loveček, M.; Puzzono, M.; van Laarhoven, H.W.M.; Carrara, S.; Ivanauskas, A.; Papiris, K.; Basso, D.; Arcidiacono, P.G.; Izbéki, F.; Chammas, R.; Vodicka, P.; Hackert, T.; Pasquali, C.; Piredda, M.L.; Costello-Goldring, E.; Cavestro, G.M.; Szentesi, A.; Tavano, F.; Włodarczyk, B.; Brenner, H.; Kreivenaite, E.; Gao, X.; Bunduc, S.; Vermeulen, R.C.H.; Schneider, M.A.; Latiano, A.; Gioffreda, D.; Testoni, S.G.G.; Kupcinskas, J.; Lawlor, R.T.; Capurso, G.; Malats, N.; Campa, D.; Canzian, F.

doi:https://doi.org/10.3389/fgene.2021.693933

Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

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Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

Lu, Y.; Corradi, C.; Gentiluomo, M.; López de Maturana, E.; Theodoropoulos, G.E.; Roth, S.; Maiello, E.; Morelli, L.; Archibugi, L.; Izbicki, J.R.; Sarlós, P.; Kiudelis, V.; Oliverius, M.; Aoki, M.N.; Vashist, Y.; van Eijck, C.H.J.; Gazouli, M.; Talar-Wojnarowska, R.; Mambrini, A.; Pezzilli, R.; Bueno-de-Mesquita, B.; Hegyi, P.; Souček, P.; Neoptolemos, J.P.; Di Franco, G.; Sperti, C.; Kauffmann, E.F.; Hlaváč, V.; Uzunoğlu, F.G.; Ermini, S.; Małecka-Panas, E.; Lucchesi, M.; Vanella, G.; Dijk, F.; Mohelníková-Duchoňová, B.; Bambi, F.; Petrone, M.C.; Jamroziak, K.; Guo, F.; Kolarova, K.; Capretti, G.; Milanetto, A.C.; Ginocchi, L.; Loveček, M.; Puzzono, M.; van Laarhoven, H.W.M.; Carrara, S.; Ivanauskas, A.; Papiris, K.; Basso, D.; Arcidiacono, P.G.; Izbéki, F.; Chammas, R.; Vodicka, P.; Hackert, T.; Pasquali, C.; Piredda, M.L.; Costello-Goldring, E.; Cavestro, G.M.; Szentesi, A.; Tavano, F.; Włodarczyk, B.; Brenner, H.; Kreivenaite, E.; Gao, X.; Bunduc, S.; Vermeulen, R.C.H.; Schneider, M.A.; Latiano, A.; Gioffreda, D.; Testoni, S.G.G.; Kupcinskas, J.; Lawlor, R.T.; Capurso, G.; Malats, N.; Campa, D.; Canzian, F.

(2021) Frontiers in Genetics, volume 12, pp. 1 - 11

(Article)

Abstract

Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA ... read more

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Keywords: genetic polymorphisms, miRNA, pancreatic cancer, pancreatic ductal adenocarcinoma, susceptibility, Molecular Medicine, Genetics, Genetics(clinical)

DOI: https://doi.org/10.3389/fgene.2021.693933

ISSN: 1664-8021

Publisher: Frontiers Media S.A.

Note: Funding Information: The research used the genotyping data provided by the EPIC, we would like to thank the contributors from the United Kingdom. The EPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC-UU_12015/1) and Cancer Research United Kingdom (C864/A14136). We are grateful to all the participants who have been part of the project and to the many members of the study teams at the University of Cambridge who have enabled this research. Funding. This work was supported by intramural funding of DKFZ; Fondazione Tizzi (www.fondazionetizzi.it); Fondazione Arpa (www.fondazionearpa.it); the Italian Ministry of Health grants (5 ? 1000); Associazione Italiana per la Ricerca sul Cancro (AIRC 5 ? 1000; 12182); Fondazione Italiana Malattie Pancreas ? Ministero Salute (FIMPCUP_J38D19000690001); Fondazione Cariverona: Oncology Biobank Project ?Antonio Schiavi? (prot. 203885/2017); the Ministry of Health of the Czechia grants (NV19-09-00088 and NV19-08-00113); Palacky University Olomouc grant (IGA_LF_2020_005); and the Ministry of Education, Youth and Sports of the Czechia project INTER-COST (LTC19015). The PanGenEU has been partially supported by Fondo de Investigaciones Sanitarias (FIS), Instituto de Salud Carlos III, Spain (PI0902102, PI12/01635, PI12/00815, PI15/01573, and PI18/01347), and EU-6FP (018771-MOLDIAG-PACA) and EU-FP7-HEALTH (259737-CANCERALIAand 256974-EPC-TM-Net) projects and in the UK by funding of EUROPAC by Pancreatic Cancer United Kingdom. The ESTHER study was funded by the Baden-W?rttemberg State Ministry of Science, Research and Arts (Stuttgart, Germany). Publisher Copyright: © Copyright © 2021 Lu, Corradi, Gentiluomo, López de Maturana, Theodoropoulos, Roth, Maiello, Morelli, Archibugi, Izbicki, Sarlós, Kiudelis, Oliverius, Aoki, Vashist, van Eijck, Gazouli, Talar-Wojnarowska, Mambrini, Pezzilli, Bueno-de-Mesquita, Hegyi, Souček, Neoptolemos, Di Franco, Sperti, Kauffmann, Hlaváč, Uzunoğlu, Ermini, Małecka-Panas, Lucchesi, Vanella, Dijk, Mohelníková-Duchoňová, Bambi, Petrone, Jamroziak, Guo, Kolarova, Capretti, Milanetto, Ginocchi, Loveček, Puzzono, van Laarhoven, Carrara, Ivanauskas, Papiris, Basso, Arcidiacono, Izbéki, Chammas, Vodicka, Hackert, Pasquali, Piredda, Costello-Goldring, Cavestro, Szentesi, Tavano, Włodarczyk, Brenner, Kreivenaite, Gao, Bunduc, Vermeulen, Schneider, Latiano, Gioffreda, Testoni, Kupcinskas, Lawlor, Capurso, Malats, Campa and Canzian.

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