Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
Wong, J.Y.Y.; Hsiung, C.A.; Matsuo, K.; Wong, M.P.; Seow, W.J.; Song, M.; Chang, I.-S.; Chatterjee, N.; Hu, W.; Wu, C.; Mitsudomi, T.; Zheng, W.; Kim, J.H.; Seow, A.; Caporaso, N.E.; Shin, M.-H.; Chung, L.P.; An, S.-J.; Zheng, H.; Yatabe, Y.; Kim, Y.T.; Cai, Q.; Kim, Y.-C.; Bassig, B.A.; Ho, J.C.M.; Ji, B.-T.; Daigo, Y.; Ito, H.; Momozawa, Y.; Ashikawa, K.; Kamatani, Y.; Honda, T.; Hosgood, H.D.; Sakamoto, H.; Kunitoh, H.; Tsuta, K.; Watanabe, S.-I.; Kubo, M.; Miyagi, Y.; Nakayama, H.; Matsumoto, S.; Tsuboi, M.; Goto, K.; Song, L.; Hua, X.; Takahashi, A.; Goto, A.; Minamiya, Y.; Shimizu, K.; Tanaka, K.; Wei, F.; Matsuda, F.; Kim, Y.H.; Oh, I.-J.; Song, F.; Su, W.-C.; Chang, G.-C.; Chen, K.-Y.; Chien, L.-H.; Xiang, Y.-B.; Kweon, S.-S.; Lee, K.-M.; Blechter, B.; Qian, B.; Lu, D.; Jeon, H.-S.; Hsiao, C.-F.; Sung, J.S.; Tsai, Y.-H.; Jung, Y.J.; Chung, C.C.; Burdett, L.; Yeager, M.; Hutchinson, A.; Berndt, S.I.; Pang, H.; Choi, J.E.; Park, K.H.; Sung, S.W.; Zhu, M.; Guan, P.; Tan, W.; Hsin, M.; Sit, K.-Y.; Ho, J.; Choi, Y.Y.; Kim, J.S.; Yoon, H.I.; Park, I.K.; Xu, P.; He, Q.; Perng, R.-P.; Vermeulen, R.; Lim, W.-Y.; Chen, K.-C.; Jin, L.; Jiang, S.-S.; Yamaji, T.; Hicks, B.; Wyatt, K.; Dai, J.; Jin, G.; Song, B.; Cheng, S.; Cui, P.; Iwasaki, M.; Shimazu, T.; Tsugane, S.; Fei, K.; Wu, G.; Lin, H.-C.; Fang, Y.-H.; Tsai, F.-Y.; Hsieh, W.-S.; Yu, J.; Stevens, V.L.; Laird-Offringa, I.A.; Marconett, C.N.; Rieswijk, L.; Chao, A.; Shu, X.-O.; Lin, D.; Chen, K.; Zhou, B.; Kohno, T.; Shen, H.; Chanock, S.J.; Rothman, N.; Lan, Q.
(2020) Genomics, volume 112, issue 2, pp. 1223 - 1232
(Article)
Abstract
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung
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adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
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Keywords: Tuberculosis, Lung cancer, Lung adenocarcinoma, Mendelian randomization, Pathway analysis
ISSN: 0888-7543
Publisher: Academic Press Inc.
Note: Cited By :3 Export Date: 8 December 2021
(Peer reviewed)
