Abstract
GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which hyperpolarizes the neuron. In early development, GABA signaling induces outward Cl− currents and is depolarizing. The postnatal shift from depolarizing to hyperpolarizing GABA
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