Bacterial Infection Disrupts Clock Gene Expression to Attenuate Immune Responses
de Leone, María José; Hernando, C. Esteban; Romanowski, Andrés; Careno, Daniel A.; Soverna, Ana Faigón; Sun, Hequan; Bologna, Nicolás G.; Vázquez, Martín; Schneeberger, Korbinian; Yanovsky, Marcelo J.
(2020) Current Biology, volume 30, issue 9, pp. 1740 - 1747.e6
(Article)
Abstract
Little is known regarding the mechanisms involved in the clock-immunity crosstalk. de Leone et al. report that the defense mutant eds4 carries a mutation in NUCLEOPORIN205 which affects its circadian function, and that leads to an attenuation of the transcriptional reprogramming in core clock genes that take place soon after
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a bacterial infection.
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Keywords: eds4, circadian clock, Enhanced Disease Susceptibility 4, LNK, NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED, NPC, Nuclear Pore Complex, plant-pathogen interactions, Biochemistry, Genetics and Molecular Biology(all), Agricultural and Biological Sciences(all)
ISSN: 0960-9822
Publisher: Cell Press
Note: Funding Information: We thank J. Hildebrandt, D. Lundberg, E. Symeonidi, and the Weigel laboratory at the Max Planck Institute for Developmental Biology in Tübingen for technical assistance in the DNA sequencing; J. Mateos and S. Mora-García for helpful discussion on the project; and P. Cerdán for suggestions for the mapping process. This work was supported by grants from the Agencia Nacional de Promoción Científica y Tecnológica of Argentina (to M.J.Y.). Funding Information: We thank J. Hildebrandt, D. Lundberg, E. Symeonidi, and the Weigel laboratory at the Max Planck Institute for Developmental Biology in T?bingen for technical assistance in the DNA sequencing; J. Mateos and S. Mora-Garc?a for helpful discussion on the project; and P. Cerd?n for suggestions for the mapping process. This work was supported by grants from the Agencia Nacional de Promoci?n Cient?fica y Tecnol?gica of Argentina (to M.J.Y.). M.J.d.L. C.E.H. D.A.C. and A.F.S. performed the experiments and statistical analysis. A.R. obtained LNK quadruple mutant. C.E.H. constructed the complementary DNA (cDNA) libraries and performed the bioinformatic analysis of the RNAseq data. M.V. performed the RNA-seq protocols. H.S. executed and K.S. supervised SHOREmapping. N.G.B. performed the nuclear and total RNA extraction. M.J.d.L. and M.J.Y. wrote the paper. M.J.Y. supervised the project. All authors discussed the results and commented on the manuscript. The authors declare no competing interests. Publisher Copyright: © 2020 Elsevier Inc.
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