Dexamethasone nanomedicines for COVID-19

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Dexamethasone nanomedicines for COVID-19
 
Lammers, Twan; Sofias, Alexandros Marios; van der Meel, Roy; Schiffelers, Raymond; Storm, Gert; Tacke, Frank; Koschmieder, Steffen; Brümmendorf, Tim H; Kiessling, Fabian; Metselaar, Josbert M
(2020) Nature Nanotechnology, volume 15, issue 8, pp. 622 - 624
(Article)
Abstract
Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.
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Keywords: Betacoronavirus/drug effects, COVID-19, Coronavirus Infections/drug therapy, Dexamethasone/therapeutic use, Humans, Nanomedicine, Pandemics, Pneumonia, Viral/drug therapy, SARS-CoV-2, Taverne
DOI: https://doi.org/10.1038/s41565-020-0752-z
ISSN: 1748-3387
Publisher: Nature Publishing Group
(Peer reviewed)
 
 
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