Note: Funding Information: We thank all the members of the Heck and Snijder laboratories for general support. This research received funding through The Netherlands Organization for Scientific Research (NWO) through the Spinoza Award SPI.2017.028 to A.J.R.H. and the ICI 024.002.009 grant to J.S. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.