Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry
Leitner, Alexander; Bonvin, Alexandre M J J; Borchers, Christoph H; Chalkley, Robert J; Chamot-Rooke, Julia; Combe, Colin W; Cox, Jürgen; Dong, Meng-Qiu; Fischer, Lutz; Götze, Michael; Gozzo, Fabio C; Heck, Albert J R; Hoopmann, Michael R; Huang, Lan; Ishihama, Yasushi; Jones, Andrew R; Kalisman, Nir; Kohlbacher, Oliver; Mechtler, Karl; Moritz, Robert L; Netz, Eugen; Novak, Petr; Petrotchenko, Evgeniy; Sali, Andrej; Scheltema, Richard A; Schmidt, Carla; Schriemer, David; Sinz, Andrea; Sobott, Frank; Stengel, Florian; Thalassinos, Konstantinos; Urlaub, Henning; Viner, Rosa; Vizcaíno, Juan A; Wilkins, Marc R; Rappsilber, Juri
(2020) Structure, volume 28, issue 11, pp. 1259 - 1268
(Article)
Abstract
Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural
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biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.
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ISSN: 1878-4186
Publisher: Cell Press
Note: Copyright © 2020.
(Peer reviewed)
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