Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization

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Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization
 
Cao, Yujie; Lipka, Joanna; Stucchi, Riccardo; Burute, Mithila; Pan, Xingxiu; Portegies, Sybren; Tas, Roderick; Willems, Jelmer; Will, Lena; MacGillavry, Harold; Altelaar, Maarten; Kapitein, Lukas C.; Harterink, Martin; Hoogenraad, Casper C.
(2020) Current Biology, volume 30, issue 5, pp. 899 - 908.e6
(Article)
Abstract
Neuronal dendrites are characterized by an anti-parallel microtubule organization. The mechanism that regulates dendritic microtubule organization is still unclear. Cao et al. demonstrate that the microtubule minus-end binding protein CAMSAP2 and kinesin-14 motor KIFC3 work together to organize dendritic microtubules and control dendrite branching.
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Keywords: CAMSAP2, dendrite, KIFC3, kinesin, MAP, microtubule minus-end, microtubule organization, motor protein, neuron, General Biochemistry,Genetics and Molecular Biology, General Agricultural and Biological Sciences
DOI: https://doi.org/10.1016/j.cub.2019.12.056
ISSN: 0960-9822
Publisher: Cell Press
(Peer reviewed)
 
 
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