Cancer-ID: towards identification of cancer by tumor-derived extracellular vesicles in blood
Rikkert, L G; Beekman, P; Caro, J; Coumans, F A W; Enciso Martinez, A; Jenster, G; Le Gac, S; Lee, W; Van Leeuwen, Ton G; Loozen, G B; Nanou, A; Nieuwland, R; Offerhaus, H L; Otto, C; Pegtel, D M; Piontek, M C; Van Der Pol, E; De Rond, L; Roos, W H; Schasfoort, R B M; Wauben, Marca; Zuilhof, H; Terstappen, Leon WMM
(2020) Frontiers in Oncology, volume 10
(Article)
Abstract
Extracellular Vesicles (EVs) have great potential as biomarkers since their composition and concentration in biofluids are disease state-dependent and their cargo can contain disease related information. Large tumor-derived EVs (tdEVs, > 1 μm) in blood from cancer patients are associated with poor outcome and changes in their number can be
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used to monitor therapy effectiveness. Whereas small tumor-derived EVs (
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Keywords: Atomic Force Microscopy, Cell-Derived Microparticles, Electrochemistry, Exosomes, Flow Cytometry, Raman spectrum analysis, Scanning electron microscopy, Surface Plasmon Resonance, extracellular vesicles, fluorescence microscopy, transmission electron microscopy 3
ISSN: 2234-943X
Publisher: Frontiers Media S.A.
(Peer reviewed)
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