Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs
Schuurman, Wouter; Levett, Peter A; Pot, Michiel W; van Weeren, Paul René; Dhert, Wouter J A; Hutmacher, Dietmar W; Melchels, Ferry P W; Klein, Travis J; Malda, Jos
(2013) Macromolecular Bioscience, volume 13, issue 5, pp. 551 - 561
(Article)
Abstract
Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at
... read more
37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.
show less
Download/Full Text
Embargo until January 01 2050
Keywords: Acrylamides, Animals, Biocompatible Materials, Bioprinting, Cartilage, Cell Survival, Compressive Strength, Cross-Linking Reagents, DNA, Gelatin, Glycosaminoglycans, Horses, Hyaluronic Acid, Hydrogels, Immunohistochemistry, Materials Testing, Mechanical Phenomena, Temperature, Tissue Engineering, Tissue Scaffolds, Ultraviolet Rays
ISSN: 1616-5187
Publisher: Wiley-VCH Verlag
Note: Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
(Peer reviewed)