Air-liquid interface exposure of in vitro lung models:improvement and application to study inhalation toxicity of aircraft-related air pollutants

Abstract

We optimize in vitro lung models under prolonged ALI culture conditions for investigating the adverse health effects of air pollutants that are emitted by and in aircrafts.We found that exposure to aircraft-related air pollutants, airport UFPs and the generated cabin fumes, can induce considerable lung toxicity, highlighting their potential inhalation risks under real-life exposure conditions.