Abstract
The retention capacity factor (kIAM) on immobilized artificial membrane chromatography columns (IAM-HPLC) is widely used as experimental descriptor of lipophilicity. For predominantly ionized compounds, however, unexpected and significant effects of pH, buffers, and salinity on kIAM have been reported. Besides zwitterionic phospholipids, IAM particles contain acidic silanol moieties and positively
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