Progesterone receptors in human meningiomas and their relation with proteins involved in apoptosis

Abstract

In summary, we hypothesize that PR might be important for the regulation of proteins involved in apoptosis. Both apoptotic proteins and PR are described as prognostic markers for tumor grade, survival and recurrence in literature. Although minute quantities of ER are present in eningiomas, exact regulation of PR in these tumors is not known and the involvement of estrogens is considered to be not very likely. Meningiomas with high PR expression express relatively more PR-A and this might have consequences for the success of an anti-tumor endocrine therapy.