Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG

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Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG
 
Fajardo, Raquel Dávila; van den Heuvel-Eibrink, Marry M.; van Tinteren, Harm; Spreafico, Filippo; Acha, Thomas; Bergeron, Christophe; de Camargo, Beatriz; Oldenburger, Foppe; Rübe, Christian; Oue, Takaharu; Vokuhl, Christian; de Krijger, Ronald R.; Vujanic, Gordan; Sebire, Neil; Coulomb-L'Hermine, Aurore; Collini, Paola; Gandola, Lorenza; Pritchard-Jones, Kathy; Graf, Norbert; Janssens, Geert O.; van Grotel, Martine
(2020) Pediatric Blood and Cancer, volume 67, issue 2
(Article)
Abstract
Background: As a significant proportion of relapses occurred in the tumor bed or abdomen on patients with the fifth National Wilms Tumor Study stage I anaplastic Wilms tumor (WT), flank radiotherapy was added for stage I anaplastic WT in the subsequent study of the Children's Oncology Group (AREN0321). Preliminary results ... read more
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Keywords: diffuse anaplasia, radiotherapy, stage I, Wilms tumor, Hematology, Oncology, Pediatrics, Perinatology, and Child Health, Journal Article
DOI: https://doi.org/10.1002/pbc.28039
ISSN: 1545-5009
Publisher: Wiley-Liss Inc.
Note: Funding Information: We dedicate this work to Prof. I. Leuschner who has contributed tremendously to the development and activities of the pathology review group of the SIOP-RTSG. Prof. I. Leuschner unfortunately passed away on January 29, 2017. The SIOP WT 2001 study was funded by Cancer Research UK (grant C1188/A8687), the UK National Cancer Research Network and Children's Cancer and Leukemia Group (which supported the UK section), Société Française des Cancers de l'Enfant and Association Leon Berard Enfant Cancéreux and Enfant et Santé (which supported the French section), Gesellschaft für Pädiatrische Onkologie und Hämatologie and Deutsche Krebschilfe (grant 50-2709-Gr2, which supported the German section), Grupo Cooperativo Brasileiro para o Tratamento do Tumor de Wilms and Sociedade Brasileira de Oncologia Pediátrica (which supported the Brazilian section), the Spanish Society of Pediatric Haematology and Oncology and the Spanish Association Against Cancer (which supported the Spanish section), and SIOP-NL. KP-J is partly supported by the National Institute for Health Research Biomedical Research Centre Funding Scheme. We acknowledge the enormous efforts made by more than 1000 clinicians working at the 251 childhood cancer treatment centers in this study from 28 countries who enrolled and followed up patients in this study, and the patients and their families for their participation. Funding Information: The SIOP WT 2001 study was funded by Cancer Research UK (grant C1188/A8687), the UK National Cancer Research Network and Children's Cancer and Leukemia Group (which supported the UK section), Société Française des Cancers de l'Enfant and Association Leon Berard Enfant Cancéreux and Enfant et Santé (which supported the French section), Gesellschaft für Pädiatrische Onkologie und Hämatologie and Deutsche Krebschilfe (grant 50‐2709‐Gr2, which supported the German section), Grupo Cooperativo Brasileiro para o Tratamento do Tumor de Wilms and Sociedade Brasileira de Oncologia Pediátrica (which supported the Brazilian section), the Spanish Society of Pediatric Haematology and Oncology and the Spanish Association Against Cancer (which supported the Spanish section), and SIOP‐NL. KP‐J is partly supported by the National Institute for Health Research Biomedical Research Centre Funding Scheme. We acknowledge the enormous efforts made by more than 1000 clinicians working at the 251 childhood cancer treatment centers in this study from 28 countries who enrolled and followed up patients in this study, and the patients and their families for their participation. Publisher Copyright: © 2019 Wiley Periodicals, Inc.
(Peer reviewed)