Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits
Haagmans, Bart L; van den Brand, Judith M A; Provacia, Lisette B; Raj, V Stalin; Stittelaar, Koert J; Getu, Sarah; de Waal, Leon; Bestebroer, Theo M; Amerongen, Geert van; Verjans, Georges M G M; Fouchier, Ron A M; Smits, Saskia L.; Kuiken, Thijs; Osterhaus, Albert D M E
(2015) Journal of Virology, volume 89, issue 11, pp. 6131 - 5
(Article)
Abstract
The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms
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were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.
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Keywords: Animals, Asymptomatic Diseases, Coronavirus Infections, Cricetinae, Disease Models, Animal, Female, Lung, Mice, Middle East Respiratory Syndrome Coronavirus, Rabbits, Respiratory System, Virus Shedding, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
ISSN: 0022-538X
Publisher: American Society for Microbiology
Note: Copyright © 2015, American Society for Microbiology. All Rights Reserved.
(Peer reviewed)