Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors
Lam, Bonnie Yin Ka; Leung, Kam Tat; Yiu, Brian; Zhao, Lei; Biesbroek, J. Matthijs; Au, Lisa; Tang, Yumi; Wang, Kai; Fan, Yuhua; Fu, Jian Hui; Xu, Qun; Song, Haiqing; Tian, Xiaolin; Chu, Winnie Chiu Wing; Abrigo, Jill; Shi, Lin; Ko, Ho; Lau, Alexander; Duering, Marco; Wong, Adrian; Mok, Vincent Chung Tong
(2019) Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, volume 11, pp. 721 - 729
(Article)
Abstract
Introduction: Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods: We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to
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assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes. Results: PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion: PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations.
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Keywords: Community subjects, Diffusion tensor imaging, Peak width of skeletonized mean diffusivity, Processing speed, Small vessel disease, Clinical Neurology, Psychiatry and Mental health, Journal Article
ISSN: 2352-8729
Publisher: John Wiley & Sons, Ltd.
Note: Funding Information: The authors would also like to acknowledge Prof. Geert Jan Biessels for his comments on the manuscript; our research staffs Eugene Siu Kai Lo, Pauline Kwan, Rachel Chau, Iris Cheng, and Anthea Yee Tung Ng for recruiting subjects, performing neuropsychological assessments, data collection, and data entry; as well as all the subjects for their participation and support to this study. This study was financially supported by the National Key Research and Development Program of China (grant number 2016YFC1300600), General Research Fund (grant number GRF CUHK 471911) and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Centre for Prevention of Dementia (in memory of Donald H. K. Chow). Ethics approval: The Joint Chinese University of Hong Kong-New Territories East Cluster Ethics Committee (ethics approval reference number: CRE-2011.090). Funding Information: This study was financially supported by the National Key Research and Development Program of China (grant number 2016YFC1300600 ), General Research Fund (grant number GRF CUHK 471911 ) and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Centre for Prevention of Dementia (in memory of Donald H. K. Chow). Publisher Copyright: © 2019 The Authors
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