Mimicking the Articular Joint with In Vitro Models
Piluso, Susanna; Li, Yang; Abinzano, Florencia; Levato, Riccardo; Moreira Teixeira, Liliana; Karperien, Marcel; Leijten, Jeroen; van Weeren, René; Malda, Jos
(2019) Trends in biotechnology, volume 37, issue 10, pp. 1063 - 1077
(Article)
Abstract
Treating joint diseases remains a significant clinical challenge. Conventional in vitro cultures and animal models have been helpful, but suffer from limited predictive power for the human response. Advanced models are therefore required to mimic the complex biological interactions within the human joint. However, the intricate structure of the joint
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microenvironment and the complex nature of joint diseases have challenged the development of in vitro models that can faithfully mimic the in vivo physiological and pathological environments. In this review, we discuss the current in vitro models of the joint and the progress achieved in the development of novel and potentially more predictive models, and highlight the application of new technologies to accurately emulate the articular joint.
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Keywords: biofabrication, homeostasis, inflammation, microfluidics, organ-on-chip, synovium, Bioengineering, Biotechnology, Review, Journal Article
ISSN: 0167-7799
Publisher: Elsevier Limited
Note: Funding Information: The authors acknowledge the financial support provided by the Dutch Arthritis Foundation ( LLP12 , LLP22 , and LLP25 ) and the financial support of the strategic alliance program entitled: Advanced biomanufacturing, funded by the University of Twente , Utrecht University and University Medical Center Utrecht , project title: Bioprinting functional tissues from stem cells and enabling biomaterials. Funding Information: The authors acknowledge the financial support provided by the Dutch Arthritis Foundation (LLP12, LLP22, and LLP25) and the financial support of the strategic alliance program entitled: Advanced biomanufacturing, funded by the University of Twente, Utrecht University and University Medical Center Utrecht, project title: Bioprinting functional tissues from stem cells and enabling biomaterials. Publisher Copyright: © 2019 Elsevier Ltd
(Peer reviewed)