Subjective cognitive decline, brain imaging biomarkers, and cognitive functioning in patients with a history of vascular disease: the SMART-Medea study
Blom, Kim; Koek, Huiberdina L; Zwartbol, Maarten H T; van der Graaf, Yolanda; Kesseler, Lara; Biessels, Geert Jan; Geerlings, Mirjam I; SMART Study Group
(2019) Neurobiology of Aging, volume 84, pp. 33 - 40
(Article)
Abstract
We estimated associations of subjective cognitive decline (SCD) with neuroimaging markers of dementia and cognitive functioning in patients with a history of vascular disease without objective cognitive impairment. Within the Second Manifestations of ARTerial disease-Memory, depression and aging study, 599 patients (62 ± 9 years) had 1.5 T brain magnetic
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resonance imaging and cognitive testing at the baseline and after 8 years of follow-up. Using multiple regression analyses, we estimated cross-sectional and longitudinal associations of SCD according to research criteria with volumes of total brain, hippocampus, white matter hyperintensities, and presence of lacunes and with memory, executive functioning, information processing speed, and working memory. SCD was associated with increased risk of lacunes at the baseline (relative risk = 1.48, 95% confidence interval: 1.03; 2.12) but not during follow-up. No significant associations with volumes of white matter hyperintensities, total brain, or hippocampus were observed. SCD was cross-sectionally associated with poorer executive functioning and speed but not during follow-up. More prospective studies are needed to further elucidate the relationship between SCD, brain imaging markers, and cognitive decline and the role of SCD in the preclinical stage of Alzheimer's disease.
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Keywords: Brain volume, Cognition, Hippocampal volume, Lacunes of presumed vascular origin, Subjective cognitive decline, White matter hyperintensities, Clinical Neurology, Geriatrics and Gerontology, Ageing, General Neuroscience, Developmental Biology, Journal Article
ISSN: 0197-4580
Publisher: Elsevier Inc.
Note: Funding Information: Financial support was received by the Alzheimer Nederland—Internationale Stichting Alzheimer Onderzoek (AN-ISAO) (Grant number 12504 ). The SMART study was supported by a grant from the Netherlands Organization for Scientific Research-Medical Sciences (project No. 904-65–095 ). The funding sources had no involvement in writing of this article or the decision to submit it for publication. Funding Information: The authors gratefully acknowledge the contribution of the SMART research nurses; R. van Petersen (data manager); B.G.F. Dinther (vascular manager) and the participants of the SMART Study Group: Y. van der Graaf, MD, PhD; D.E. Grobbee, MD, PhD; G.E.H.M. Rutten, MD, PhD, Julius Center for Health Sciences and Primary care; F.L.J. Visseren, MD, PhD, Department of Internal Medicine; G.J. de Borst, MD, PhD, Department of Vascular Surgery; L.J. Kappelle, MD, PhD, Department of Neurology; T. Leiner, MD, PhD, Department of Radiology; P.A. Doevendans, MD, PhD, Department of Cardiology. Financial support was received by the Alzheimer Nederland—Internationale Stichting Alzheimer Onderzoek (AN-ISAO) (Grant number 12504). The SMART study was supported by a grant from the Netherlands Organization for Scientific Research-Medical Sciences (project No. 904-65–095). The funding sources had no involvement in writing of this article or the decision to submit it for publication. Publisher Copyright: © 2019 The Authors
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