Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin

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Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the Oprd Outer Membrane Porin
 
Fluit, Ad C; Rentenaar, Rob J; Ekkelenkamp, Miquel B; Severs, Tim T; Mavinkurve-Groothuis, Annelies M C; Rogers, Malbert R C; Bruin, Marrie C A; Wolfs, Tom F W
(2019) The Pediatric infectious disease journal, volume 38, issue 4, pp. 398 - 399
(Article)
Abstract
A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a Pseudomonas aeruginosa strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the oprD gene, which added ... read more
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Keywords: Pseudomonas aeruginosa, febrile neutropenia, imipenem resistant, meropenem resistant, mexR, oprD, sepsis, Microbiology (medical), Infectious Diseases, Pediatrics, Perinatology, and Child Health, Journal Article
DOI: https://doi.org/10.1097/INF.0000000000002244
ISSN: 0891-3668
Publisher: Lippincott Williams and Wilkins
Note: Publisher Copyright: © 2019 Wolters Kluwer Health, Inc. All rights reserved.
(Peer reviewed)