A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion

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A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
 
Torpe, Nanna; Gopal, Sandeep; Baltaci, Oguzhan; Rella, Lorenzo; Handley, Ava; Korswagen, Hendrik C.; Pocock, Roger
(2019) Cell Reports, volume 26, issue 12, pp. 3183 - 3190.e5
(Article)
Abstract
Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding catalyst and chaperone, controls secretion of the Caenorhabditis elegans ... read more
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Keywords: neuronal migration, protein disulfide isomerase, Wnt morphogen, Wnt secretion, General Biochemistry,Genetics and Molecular Biology
DOI: https://doi.org/10.1016/j.celrep.2019.02.072
ISSN: 2211-1247
Publisher: Cell Press
Note: Funding Information: We thank members of the Pocock Laboratory and Brent Neumann for comments on the manuscript. Some strains were provided by the Caenorhabditis Genetics Center (University of Minnesota), which is funded by NIH Office of Research Infrastructure Programs ( P40 OD010440 ). This work was supported by the following grants: Monash University Senior Postdoctoral Fellowship to S.G., NWO-ALW (Open Program Grant 822.02.012 ) to H.C.K., European Research Council (ERC Starting Grant 260807 to R.P.), Lundbeck Foundation (Project R67-A6094 to R.P.), NHMRC (Project GNT1105374 and Senior Research Fellowship GNT1137645 to R.P.), and veski innovation fellowship ( VIF23 to R.P.). Funding Information: We thank members of the Pocock Laboratory and Brent Neumann for comments on the manuscript. Some strains were provided by the Caenorhabditis Genetics Center (University of Minnesota), which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). This work was supported by the following grants: Monash University Senior Postdoctoral Fellowship to S.G., NWO-ALW (Open Program Grant 822.02.012) to H.C.K., European Research Council (ERC Starting Grant 260807 to R.P.), Lundbeck Foundation (Project R67-A6094 to R.P.), NHMRC (Project GNT1105374 and Senior Research Fellowship GNT1137645 to R.P.), and veski innovation fellowship (VIF23 to R.P.). Publisher Copyright: © 2019 The Author(s)
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