An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

Cosgarea, I; Koelsch, B; Fischer, C; Griewank, K G; van den Berg, L; Kutritz, A; Schadendorf, D; Kindler-Röhrborn, A

doi:https://doi.org/10.1016/j.jid.2019.03.1154

An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

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An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1)

Cosgarea, I; Koelsch, B; Fischer, C; Griewank, K G; van den Berg, L; Kutritz, A; Schadendorf, D; Kindler-Röhrborn, A

(2019) Journal of Investigative Dermatology, volume 139, issue 10, pp. 2235 - 2238.e5

(Article)

Abstract

Using inbred BN and LE/Stm rats susceptible and resistant, respectively, to chemically induced cutaneous cyst development we were able to further unveil the genetic architecture of inherited multiple cyst formation. N-methyl-N-nitrosourea-treated (BN x LE) F2 intercross rats proved to develop differential numbers of cutaneous cysts, demonstrating epidermal, trichilemmal and verrucous ... read more

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Keywords: Dermatology, Molecular Biology, Biochemistry, Cell Biology, Journal Article

DOI: https://doi.org/10.1016/j.jid.2019.03.1154

ISSN: 0022-202X

Publisher: Nature Publishing Group

Note: Funding Information: This study was funded by the Federal Ministry of Research and Technology (BMBF) grant number 01FP1062/63 . The authors thank Armin Daschke and Marcus Linnenboden, Central Animal Facility, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany, for expert assistance with animal husbandry.

(Peer reviewed)