The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan

Rabouille, Catherine

doi:https://doi.org/10.1016/j.molcel.2019.03.038

The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan

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The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan

Rabouille, Catherine

(2019) Molecular Cell, volume 74, issue 2, pp. 225 - 226

(Article)

Abstract

The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function.

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Keywords: Animals, Basic Helix-Loop-Helix Transcription Factors, Drosophila, Drosophila Proteins, Longevity, Journal Article, Comment

DOI: https://doi.org/10.1016/j.molcel.2019.03.038

ISSN: 1097-2765

Publisher: Cell Press

(Peer reviewed)