Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Lipka, Joanna; Hoogenraad, Casper C

doi:https://doi.org/10.1016/j.neuron.2019.10.021

Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

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Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity

Lipka, Joanna; Hoogenraad, Casper C

(2019) Neuron, volume 104, issue 3, pp. 429 - 430

(Article)

Abstract

Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

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DOI: https://doi.org/10.1016/j.neuron.2019.10.021

ISSN: 0896-6273

Publisher: Cell Press

(Peer reviewed)

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