Warming nerves for excitability testing
Kovalchuk, Maria O; Franssen, Hessel; Scheijmans, Féline E V; van Schelven, Leonard J; van den Berg, Leonard H; Sleutjes, Boudewijn T H M
(2019) Muscle & Nerve, volume 60, issue 3, pp. 279 - 285
(Article)
Abstract
Introduction: The aim of this study was to find the best method of warming the median nerve before excitability testing to a standard temperature. Methods: In 5 healthy subjects, the forearm and hand were warmed for 1 h to 37°C by infrared lamp, water blanket, or water bath. Recordings were
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performed before and during warming every 10 min. Excitability indices were fitted by exponential relations, thereby calculating the time needed to reach 95% of their asymptotic end value. Results: Distal motor latency, refractory period, and superexcitability at 10 ms changed exponentially with time. Warming by water bath took the shortest time (24 min); this was followed by warming by infrared lamp (34 min) and water blanket (35 min). Conclusions: Warming by water bath is the quickest way. The other methods took only moderately more time. Future studies need to specify both warming method and warming time before excitability testing. Muscle Nerve, 2019.
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Keywords: excitability, infrared lamp, temperature, warming, water bath, water blanket, Clinical Neurology, Physiology (medical), Cellular and Molecular Neuroscience, Physiology, Journal Article
ISSN: 0148-639X
Publisher: John Wiley and Sons Inc.
Note: Funding Information: Abbreviations: CMAP, compound muscle action potential; DML, distal motor latency; HCN, hyperpolarization-activated cyclic nucleotide-gated channels; IQR, interquartile range; I/V, current-voltage relationship; SDTC, strength-duration time constant. Key words: excitability; infrared lamp; temperature; warming; water bath; water blanket Funding: This project was supported by the European Federation of Neurological Societies scientific Fellowship and grant W.OR14-07 from the Prinses Beatrix Spierfonds. Conflicts of Interest: None of the authors has any conflict of interest to disclose. Publisher Copyright: © 2019 Wiley Periodicals, Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
(Peer reviewed)