Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy
Stork, Abraham C J; Rijkers, Ger T; Vlam, Lotte; Cats, Elisabeth A; de Jong, Ben A W; Fritsch-Stork, Ruth D E; Veldink, Jan H; van den Berg, Leonard H; Notermans, Nicolette C; van der Pol, W-Ludo
(2019) Muscle & Nerve, volume 59, issue 6, pp. 694 - 698
(Article)
Abstract
Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods: To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and
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113 controls. Results: Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy. Discussion: Median IL-6 and IL-10 serum concentrations differ between patients with anti-MAG neuropathy and other patients with IgM-PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune-mediated disease mechanisms. Muscle Nerve 59:694–698, 2019.
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Keywords: anti-MAG neuropathy, cytokines, monoclonal gammopathy, multifocal motor neuropathy, peripheral neuropathy, Immunoglobulin M/immunology, Humans, Middle Aged, Cytokines/immunology, Male, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology, Interleukin-2/immunology, Interferon-gamma/immunology, Interleukin-6/immunology, Polyneuropathies/immunology, Aged, 80 and over, Interleukin-10/immunology, Adult, Female, Paraproteinemias/immunology, Myelin-Associated Glycoprotein/immunology, Interleukin-12/immunology, Autoantibodies/immunology, Interleukin-4/immunology, Interleukin-8/immunology, Tumor Necrosis Factor-alpha/immunology, B-Lymphocytes/immunology, Granulocyte-Macrophage Colony-Stimulating Factor/immunology, Aged, Clinical Neurology, Physiology (medical), Cellular and Molecular Neuroscience, Physiology, Journal Article
ISSN: 0148-639X
Publisher: John Wiley and Sons Inc.
Note: © 2019 Wiley Periodicals, Inc.
(Peer reviewed)