Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis

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Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis
 
Brouwer, Arwin J.; Elgersma, Ronald C.; Jagodzinska, Monika; Rijkers, Dirk T.S.; Liskamp, Rob M.J.
(2008) Bioorganic and Medicinal Chemistry Letters, volume 18, issue 1, pp. 78 - 84
(Article)
Abstract
The synthesis of a new peptidomimetic structure, the alkene dipeptidosulfonamide isostere, is described. The synthesis is based on a cross metathesis reaction between two allylic building blocks, both in solution and on the solid phase. This method was also applicable to the solid phase synthesis of alkene dipeptide isosteres. Derivatives ... read more
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Keywords: Alkenedipeptide isosteres, Alkenedipeptidosulfonamide isosteres, Amyloid, Peptidomimetics, Solid phase cross metathesis, alkene, amylin, dipeptide, dipeptidosulfonamide, sulfonamide, unclassified drug, article, chemical structure, circular dichroism, electrospray mass spectrometry, enzymatic degradation, fiber, peptide synthesis, solid phase synthesis, transmission electron microscopy, Wittig reaction
DOI: https://doi.org/10.1016/j.bmcl.2007.11.009
ISSN: 0960-894X
Publisher: Elsevier
(Peer reviewed)
 
 
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