Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands

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Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands
 
Arnusch, Christopher J.; André, Sabine; Valentini, Paola; Lensch, Martin; Russwurm, Roland; Siebert, Hans-Christian; Fischer, Marcel J. E.; Gabius, Hans-Joachim; Pieters, Roland J.
(2004) Bioorganic and Medicinal Chemistry Letters, volume 14, issue 6, pp. 1437 - 1440
(Article)
Abstract
A library of pentapeptides containing the sequence -Y-X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry. © 2004 Elsevier Ltd. ... read more
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Keywords: carbohydrate, galactose, galectin, lectin, ligand, pentapeptide, amino acid sequence, article, library, nuclear magnetic resonance, protein analysis, protein binding, protein modification
DOI: https://doi.org/10.1016/j.bmcl.2004.01.029
ISSN: 0960-894X
Publisher: Elsevier
(Peer reviewed)
 
 
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