Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate

Reichel, Frank; Ashton, Peter R.; Boons, Geert Jan

doi:https://doi.org/10.1039/a704127f

Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate

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Synthetic carbohydrate-based vaccines: Synthesis of an L-glycero-D-manno-heptose antigen-T-epitope-lipopeptide conjugate

Reichel, Frank; Ashton, Peter R.; Boons, Geert Jan

(1997) Chemical Communications, issue 21, pp. 2087 - 2088

(Article)

Abstract

A facile and highly efficient synthesis of a glycopeptidolipid containing a heptose sugar, a synthetic T-epitope and a synthetic immunoadjuvant is presented which represents an important step towards the development of a fully synthetic vaccine against Neisseria meningitidis.

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Keywords: Catalysis, Electronic, Optical and Magnetic Materials, Ceramics and Composites, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Materials Chemistry

DOI: https://doi.org/10.1039/a704127f

ISSN: 1359-7345

Publisher: Royal Society of Chemistry

(Peer reviewed)

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