A two-directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H

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A two-directional and highly convergent approach for the synthesis of the tumor-associated antigen Globo-H
 
Zhu, Tong; Boons, Geert Jan
(1999) Angewandte Chemie - International Edition, volume 38, issue 23, pp. 3495 - 3497
(Article)
Abstract
The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.
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Keywords: Antigens, Chemoselectivity, Glycosylations, Oligosaccharides, General Chemistry
DOI: https://doi.org/10.1002/(SICI)1521-3773(19991203)38:23<3495::AID-ANIE3495>3.0.CO;2-X
ISSN: 1433-7851
Publisher: John Wiley and Sons Ltd
(Peer reviewed)
 
 
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