Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
Berkers, Gitte; van Mourik, Peter; Vonk, Annelotte M; Kruisselbrink, Evelien; Dekkers, Johanna F; de Winter-de Groot, Karin M; Arets, Hubertus G M; Marck-van der Wilt, Rozemarijn E P; Dijkema, Jasper S; Vanderschuren, Maaike M; Houwen, Roderick H J; Heijerman, Harry G M; van de Graaf, Eduard A; Elias, Sjoerd G; Majoor, Christof J; Koppelman, Gerard H; Roukema, Jolt; Bakker, Marleen; Janssens, Hettie M; van der Meer, Renske; Vries, Robert G J; Clevers, Hans C; de Jonge, Hugo R; Beekman, Jeffrey M; van der Ent, Cornelis K
(2019) Cell Reports, volume 26, issue 7, pp. 1701 - 1708.e3
(Article)
Abstract
Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.
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Keywords: CFTR, cystic fibrosis, drug response, organoids, personalized treatment, predicting, stem cell cultures, Journal Article
ISSN: 2211-1247
Publisher: Cell Press
Note: Publisher Copyright: © 2019 The Author(s)
(Peer reviewed)
