Air pollution and airway resistance at age 8 years: The PIAMA birth cohort study
Finke, Isabelle; De Jongste, Johan C.; Smit, Henriette A.; Wijga, Alet H.; Koppelman, Gerard H.; Vonk, Judith; Brunekreef, Bert; Gehring, Ulrike
(2018) Environmental Health: A Global Access Science Source, volume 17, issue 1
(Article)
Abstract
Background: Air pollution has been found to adversely affect children’s lung function. Forced expiratory volume in 1 s and forced vital capacity from spirometry have been studied most frequently, but measurements of airway resistance may provide additional information. We assessed associations of long-term air pollution exposure with airway resistance. Methods:
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We measured airway resistance at age 8 with the interrupter resistance technique (Rint) in participants of the Dutch PIAMA birth cohort study. We linked Rint with estimated annual average air pollution concentrations [nitrogen oxides (NO2, NOx), PM2.5 absorbance (“soot”), and particulate matter < 2.5 μm (PM2.5), < 10 μm (PM10) and 2.5-10 μm (PMcoarse)] at the birth address and current home address (n = 983). Associations between air pollution exposure and interrupter resistance (Rint) were assessed using multiple linear regression adjusting for potential confounders. Results: We found that higher levels of NO2 at the current address were associated with higher Rint [adj. mean difference (95% confidence interval) per interquartile range increase in NO2: 0.018 (0.001, 0.035) kPa·s·L− 1]. Similar trends were observed for the other pollutants, except, PM10. No association was found between Rint and exposure at the birth address. Conclusions: Our results support the hypothesis that air pollution exposure is associated with a lower lung function in schoolchildren.
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Keywords: Air pollution, Children, Interrupter resistance, Nitrogen dioxide, Particulate matter, Public Health, Environmental and Occupational Health, Health, Toxicology and Mutagenesis
ISSN: 1476-069X
Publisher: BioMed Central
Note: Funding Information: Professor Gerard H. Koppelman reports grants from the Lung Foundation Netherlands, TEVA Netherlands, the UBBO EMMIUS Foundation, and the TETRI Foundation outside the submitted work. Funding Information: The PIAMA study has received funding from the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research, the Lung Foundation Netherlands (previously Asthma Fund), the Netherlands Ministry of Spatial Planning, Housing, and the Environment, and the Netherlands Ministry of Health, Welfare, and Sport. Ulrike Gehring was supported by a research fellowship from the Netherlands Organization for Scientific Research (NWO).The sponsors had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the report for publication. Publisher Copyright: © 2018 The Author(s).
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