Solid-state NMR on complex biomolecules: Methods and applications

Abstract

Solid-state NMR (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity. In the following chapter, we discuss concepts to deal with the spectroscopic challenges of applying ssNMR to complex biomolecular systems and how to place structural information obtained from ssNMR in a (supra)molecular context. Applications range from protein biopolymers and hydrogels to drug delivery systems, biosilica, and other biomaterials.