Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

Note: Funding Information: received speaker honoraria from Servier, Boehringer Ingelheim, Bayer, Bristol Myers Squibb, Pfizer, Daiichi Sankyo, Novartis and Berlin Chemie. M.L. serves as an advisor to MSD, Boehringer Ingelheim, Novo Nordisk, Amgen and received speaker honoraria from MSD, Boehringer Ingelheim, Novo Nordisk, Amgen, Sanofi, Bayer, Lilly, Astra Zeneca. J.B. serves as an advisor to and received speaker honoraria from Bayer, Servier, Novartis, Boehringer Ingelheim, Bristol Myers Squibb, Pfizer, Daiichi Sankyo; he also received research support from Bayer. N.M. has served as a speaker for Amgen, Bayer, Boehringer Ingelheim, Sanofi-Aventis, MSD, BMS, AstraZeneca, Lilly, NovoNordisk; Bayer; as an advisor to Amgen, Bayer, Boehringer Ingelheim, Sanofi-Aventis, MSD, BMS, AstraZeneca, NovoNordisk, but declines all personal compensation from pharma or device companies. P.R. reports personal fees (consulting) from Novartis, Relypsa, AstraZeneca, Grünenthal, Stealth Peptides, Fresenius, Vifor Fresenius Medical Care Renal Pharma, Vifor and CTMA; lecture fees from Bayer and CVRx; cofounder of CardioRenal. K.C. is a director of T∆S Ltd, a company spun out of the University of Oxford to develop and commercialize products based on the science of ketone bodies in human nutrition. ADC received speaker honoraria from Boehringer Ingelheim, Eli Lilly, Novo Nordisk, DOC generic, MSD, AstraZeneca, Sanofi. A.R.L. serves as an advisor to Novartis, Servier, Stealth Peptides and Bristol Myers Squibb and received speaker honoraria from Novartis, Servier, Boehringer Ingelheim, AMGEN and Pfizer. MH has received speaker honoraria, advisory board fees and/or travel grants from Novartis, Roche Diagnostics, Pfizer, Vifor Pharma, Merck, Servier and BRAHMS. C.W. received honoraria of steering committee meetings and lecturing from Boehringer-Ingelheim and Genzyme-Sanofi. D.F. has received speaker honoraria, advisory board fees and/or travel grants from Novartis, Servier, Boehringer Ingelheim, Pfizer, Daiichi-Sankyo and Menarini. RB: the UMCG, which employs RB has received research grants and/or fees from AstraZeneca, Bristol-Myers Squibb, Novartis, Roche, Trevena and ThermoFisher GmbH; RB is a minority shareholder of scPharmaceuticals, Inc. and received personal fees from Novartis and Servier. All other authors declared no conflict of interest. Funding Information: 11); and the Innovational Research Incentives Scheme program of the Netherlands Organization for Scientific Research (NWO VIDI, grant 917.13.350). N.M. is supported by the DFG (SFB TRR 219M-03, M-05). H.T. is supported by grants from the National Institutes of Health of the US Public Health Service (HL-RO1 061483 and HL-RO1 073162). A.B.G. was supported by grants from the Ministerio de Educación y Ciencia (SAF2014-59892; SAF2017-84324), Fundació La MARATÓ de TV3 (201502, 201516), CIBER Cardiovascular (CB16/11/00403), and AdvanceCat 2014-2020. H.B. is supported by the DFG (Bu2126/3-1). A.D.C. was supported by ‘FIL’ funds for research from University of Parma. A.G. was supported by grants from the European Union Commission’s FP7 programme (HOMAGE and FIBROTARGETS) and ERA-CVD Joint Transnational Call 2016 LYMIT-DIS. G.R. acknowledges recent funding from The Cunningham Trust, MRC (MR/K012924/1) and the Diabetes UK RW and JM Collins studentship. S.H. received funding from the European Union Commission’s Seventh Framework programme (2007-2013) under grant agreement N° 305507 (HOMAGE), N° 602904 (FIBROTARGETS) and N° 602156 (HECATOS). S.H. acknowledges the support from the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation, CVON-ARENA-PRIME, CVON-EARLY HFPEF, and SHE-PREDICTS. This research is co-financed as a PPP-allowance Research and Innovation by the Ministry of Economic Affairs within Top Sector Life sciences & Health. Funding Information: C.M. is supported by the Deutsche Forschungsgemeinschaft (DFG; SFB 894, TRR-219, and Ma 2528/7-1), the German Federal Ministry of Education and Science (BMBF; 01EO1504) and the Corona foundation. J.B. is supported by the DFG (SFB 1118) and the DZHK (German Centre for Cardiovascular Research) and by the BMBF. M.L. is supported by the DFG (SFB TRR 219M-03). R.B. is supported by the Netherlands Heart Foundation (CVON DOSIS 2014-40, CVON SHE-PREDICTS-HF 2017-21, and CVON RED-CVD 2017-