Assessment of novel cardiovascular biomarkers in women with a history of recurrent miscarriage
Wagner, M M; Jukema, J W; Hermes, W; le Cessie, S; de Groot, C J M; Bakker, J A; van Lith, J M M; Bloemenkamp, K W M
(2018) Pregnancy Hypertension, volume 11, pp. 129 - 135
(Article)
Abstract
OBJECTIVES: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association. STUDY DESIGN: Women who visited the recurrent miscarriage
... read more
clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-up study (between 2012 and 2014). The reference group consisted of women with at least one uncomplicated pregnancy and a history of no miscarriage, matched on zip code, age, and date of pregnancy. MAIN OUTCOME MEASURES: Cardiovascular biomarkers were determined, classified into; inflammation (HsCRP, lipoprotein-associated phospholipase A2), thrombosis (homocysteine, folate, anti-cardiolipin antibodies and anti-ß-2-glycoprotein antibodies), lipid metabolism (lipoprotein(a)), renal function (creatinine, microalbuminuria), myocardial damage (N-terminal pro-brain natriuretic peptide, high sensitive TroponineT) and multiple mechanisms (albumin, vitamin D). RESULTS: In both groups, 36 women were included. Women with recurrent miscarriage had a significantly higher median HsCRP (1.49 mg/L) compared to women with no miscarriage (1.01 mg/L, p = 0.03) and a significantly lower mean albumin (46.0 vs 47.6g/L, p = 0.004) and vitamin D (55.6 vs 75.4nmol/L, p = 0.007), respectively. Differences remained after adjustments for classic cardiovascular risk factors (BMI, smoking, diabetes mellitus, and hypertension). CONCLUSIONS: Our findings suggest a proinflammatory state in women with a history of recurrent miscarriage, which suggests a less optimal health, compared to women with no miscarriage. More research (observational and intervention) is warranted to investigate the association with vitamin D.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: Abortion, Habitual/blood, Adult, Biomarkers/blood, C-Reactive Protein/analysis, Cardiovascular Diseases/blood, Case-Control Studies, Female, Follow-Up Studies, Health Status, Humans, Hypoalbuminemia/blood, Inflammation Mediators/blood, Netherlands/epidemiology, Pregnancy, Prognosis, Risk Factors, Serum Albumin, Human/analysis, Time Factors, Vitamin D/blood, Vitamin D Deficiency/blood, Young Adult, Journal Article
ISSN: 2210-7789
Publisher: Elsevier BV
Note: Copyright © 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
(Peer reviewed)