Dual-time-point FDG PET/CT imaging in prosthetic heart valve endocarditis
Scholtens, A M; Swart, L E; Verberne, H J; Budde, R P J; Lam, M G E H
(2018) Journal of Nuclear Cardiology, volume 25, issue 6, pp. 1960 - 1967
(Article)
Abstract
PURPOSE: FDG PET/CT has been of increasing interest in the diagnostic workup of prosthetic heart valve endocarditis (PVE). Some reports advocate later imaging time points to improve the diagnostic accuracy for PVE. In this study, we compared standard and late FDG PET/CT images in patients with a clinical suspicion of
... read more
PVE. MATERIALS AND METHODS: Fourteen scans in 13 patients referred for FDG PET/CT for suspicion of PVE performed at standard (60 min post injection) and late (150 min post injection) time points were scored based on visual interpretation and semi-quantitatively with SUVmax and target-to-background ratio (TBR, defined as [SUVmax valve/SUVmean blood pool]). Final diagnosis was based on surgical findings in all cases of infection (n = 6) and unremarkable follow-up in all others (n = 8). RESULTS: Late images were more prone to false positive interpretation for both visual and semi-quantitative analyses. Visual analysis of the standard images yielded 1 false negative and 1 false positive result. On the late images, no scans were false negative but 5 scans were false positive. CONCLUSION: Late FDG PET/CT imaging for PVE seems prone to false positive results. Therefore, late imaging should be interpreted with caution.
show less
Download/Full Text
Keywords: FDG PET/CT, endocarditis, prosthetic heart valve, Humans, Middle Aged, Endocarditis, Bacterial/diagnostic imaging, Prosthesis-Related Infections/diagnostic imaging, Heart Valve Prosthesis Implantation/adverse effects, Aged, 80 and over, Adult, Fluorodeoxyglucose F18, Aged, Positron Emission Tomography Computed Tomography/methods, Radiopharmaceuticals, CT, FDG PET, Cardiology and Cardiovascular Medicine, Radiology Nuclear Medicine and imaging, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 1071-3581
Publisher: Springer New York
Note: Funding Information: R.P.J. Budde has received and L.E. Swart is funded by a research Grant from the Dutch Heart Foundation (DHF 2013T071). A.M. Scholtens, H.J. Verberne, and M.G.E.H. Lam declare no conflict of interest regarding this study. All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants as part of the clinical routine before imaging procedures in our hospital. Due to the retrospective nature of the study, no study-specific informed consent applies. The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarises the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com Funding Information: R.P.J. Budde has received and L.E. Swart is funded by a research Grant from the Dutch Heart Foundation (DHF 2013T071). A.M. Scholtens, H.J. Verberne, and M.G.E.H. Lam declare no conflict of interest regarding this study. Publisher Copyright: © 2017, The Author(s).
(Peer reviewed)
