A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage
Doitsidou, Maria; Minevich, Gregory; Kroll, Jason R; Soete, Gwen; Gowtham, Sriharsh; Korswagen, Hendrik C; Sebastiaan van Zon, Jeroen; Hobert, Oliver
(2018) G3: Genes, Genomes, Genetics, volume 8, issue 1, pp. 17 - 26
(Article)
Abstract
Invertebrate and vertebrate nervous systems generate different types of dopaminergic neurons in distinct parts of the brain. We have taken a genetic approach to understand how the four functionally related, but lineally unrelated, classes of dopaminergic neurons of the nematode Caenorhabditis elegans, located in distinct parts of its nervous system,
... read more
are specified. We have identified several genes involved in the generation of a specific dopaminergic neuron type that is generated from the so-called postdeirid lineage, called PDE. Apart from classic proneural genes and components of the mediator complex, we identified a novel, previously uncharacterized zinc finger transcription factor, ztf-6 Loss of ztf-6 has distinct effects in different dopamine neuron-producing neuronal lineages. In the postdeirid lineage, ztf-6 is required for proper cell division patterns and the proper distribution of a critical cell fate determinant, the POP-1/TCF-like transcription factor.
show less
Download/Full Text
Keywords: Amino Acid Sequence, Animals, Caenorhabditis elegans/cytology, Caenorhabditis elegans Proteins/genetics, Cell Differentiation, Cell Division, Cell Lineage/genetics, DNA-Binding Proteins/genetics, Dopamine/metabolism, Dopaminergic Neurons/classification, Gene Expression Regulation, Developmental, High Mobility Group Proteins/genetics, Mutation, Transcription Factors/genetics, Zinc Fingers
ISSN: 2160-1836
Publisher: Genetics Society of America
Note: Copyright © 2018 Doitsidou et al.
(Peer reviewed)
See more statistics about this item