Note: Funding Information: The research leading to these results was conducted as part of the IMI GetReal consortium. For further information please refer to www.imi-getreal.eu. This paper only reflects the personal views of the stated authors. The authors thank Kit Roes for his input on the thinking that went into this paper. The work leading to these results has received support from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no. 115546, resources of which are composed of financial contribution from the EU's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in-kind contribution. Funding Information: The research leading to these results was conducted as part of the IMI GetReal consortium. For further information please refer to www.imi-getreal.eu . This paper only reflects the personal views of the stated authors. The authors thank Kit Roes for his input on the thinking that went into this paper. The work leading to these results has received support from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no. 115546 , resources of which are composed of financial contribution from the EU’s Seventh Framework Programme ( FP7/2007-2013 ) and EFPIA companies ’ in-kind contribution. Funding Information: The research leading to these results was conducted as part of the IMI GetReal consortium. For further information please refer to www.imi-getreal.eu. This paper only reflects the personal views of the stated authors. The authors thank Kit Roes for his input on the thinking that went into this paper. The work leading to these results has received support from the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no. 115546, resources of which are composed of financial contribution from the EU's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies? in-kind contribution.